Relationship Between Neutrophil–Lymphocyte Ratio and Isolated Low High-Density Lipoprotein Cholesterol

Several studies showed that high-density lipoprotein cholesterol (HDL-C) has anti-inflammatory effect. The neutrophil–lymphocyte ratio (NLR) is a new biomarker of systemic inflammation. The aim of this study was to assess the NLR in healthy participants with low HDL-C. We studied 69 patients with lo...

Full description

Saved in:
Bibliographic Details
Published in:Angiology 2014-08, Vol.65 (7), p.630-633
Main Authors: Varol, Ercan, Bas, Hasan Aydin, Aksoy, Fatih, Ari, Hatem, Ozaydin, Mehmet
Format: Article
Language:English
Subjects:
Adult
Aged
Cholesterol, LDL - blood
Female
Humans
Inflammation - blood
Leukocyte Count
Lipoproteins, HDL - blood
Lymphocytes - cytology
Male
Middle Aged
Neutrophils - cytology
Risk Factors
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies showed that high-density lipoprotein cholesterol (HDL-C) has anti-inflammatory effect. The neutrophil–lymphocyte ratio (NLR) is a new biomarker of systemic inflammation. The aim of this study was to assess the NLR in healthy participants with low HDL-C. We studied 69 patients with low HDL-C (≤35 mg/dL) and 59 control participants (HDL-C >35 mg/dL) with similar cardiovascular risk factors. Hematological indices were measured in all patients with low HDL-C and control participants. The HDL-C was significantly lower among the patients with low HDL-C than that of the control group (31.7 ± 2.7 vs 50.7 ± 5.0 mg/dL, respectively; P < .001). The NLR was significantly higher among the patients with low HDL-C than that of the control group (2.6 ± 0.8 vs 1.6 ± 0.4, respectively; P < .001). The NLR was negatively correlated with HDL-C (P < .001, r = −.53). The NLR is significantly elevated in patients with low HDL-C when compared with control participants.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319713497992