The derived neutrophil/lymphocyte ratio predicts poor clinical outcome in soft tissue sarcoma patients

Abstract Background Inflammation plays an important role in tumor proliferation and survival in cancer patients. The aim of this study was to investigate the prognostic impact of the pre-operative–derived neutrophil/lymphocyte ratio (dNLR) in a large cohort of soft tissue sarcoma (STS) patients afte...

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Published in:The American journal of surgery 2015-07, Vol.210 (1), p.111-116
Main Authors: Szkandera, Joanna, M.D, Gerger, Armin, M.D, Liegl-Atzwanger, Bernadette, M.D, Stotz, Michael, M.D, Samonigg, Hellmut, M.D, Friesenbichler, Joerg, M.D, Stojakovic, Tatjana, M.D, Leithner, Andreas, M.D, Pichler, Martin, M.D
Format: Article
Language:English
Subjects:
Abdomen
Age
Aged
Cancer therapies
Clinical outcomes
Clinical trials
Confidence intervals
Derived neutrophil/lymphocyte ratio
Disease
Disease-Free Survival
Female
Humans
Inflammation
Laboratories
Leukocyte Count
Lymphocytes
Male
Medical prognosis
Middle Aged
Mortality
Multivariate analysis
Neutrophils
Predictive Value of Tests
Prognostic marker
Retrospective Studies
Sarcoma - blood
Sarcoma - surgery
Soft Tissue Neoplasms - blood
Soft Tissue Neoplasms - surgery
Soft tissue sarcoma
Surgery
Treatment Outcome
Tumors
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Summary:Abstract Background Inflammation plays an important role in tumor proliferation and survival in cancer patients. The aim of this study was to investigate the prognostic impact of the pre-operative–derived neutrophil/lymphocyte ratio (dNLR) in a large cohort of soft tissue sarcoma (STS) patients after curative surgical resection. Methods The impact of preoperative dNLR on disease-free survival (DFS) and overall survival (OS) in retrospectively evaluated 340 STS patients was assessed using Kaplan–Meier curves and Cox proportional models. Results Applying receiver operating curve analysis, we determined a cut-off value of 2.39 for the dNLR to be optimal for discrimination of patients' survival in the whole cohort. Kaplan–Meier curves revealed a dNLR greater than or equal to 2.39 as a marker for decreased DFS ( P = .031) and OS ( P = .007, log-rank test) in STS patients. In multivariate analysis, increased dNLR was significantly associated with poor OS (hazard ratio 1.60, 95% confidence interval 1.07 to 2.40, P = .022). Conclusions This study demonstrates that preoperative dNLR might represent a well-correlated surrogate marker for the widely validated NLR. The dNLR is easily obtainable and can provide important information for individual risk assessment in clinical trials.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.10.021