Determining the persistence of maternally acquired antibodies to hepatitis A and varicella zoster during the first 2 years of life in Turkey

Vaccination should be timed to take into account the potential interference of maternal antibodies. The purpose of this study was to determine the persistence of maternally acquired antibodies to hepatitis A and varicella zoster in a group of healthy infants between 6 and 24 months of age. These inf...

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Bibliographic Details
Published in:European journal of pediatrics 2015-07, Vol.174 (7), p.883-890
Main Authors: Begde, Fırat, Orhon, Filiz Simsek, Gerceker, Devran, Ulukol, Betul, Topcu, Seda, Baskan, Sevgi
Format: Article
Language:English
Subjects:
Age
Antibodies
Antibodies, Viral - blood
Chicken pox
Child, Preschool
Female
Hepatitis A
Hepatitis A Antibodies - blood
Hepatitis A virus
Herpesvirus 3, Human - immunology
Humans
Immunity, Maternally-Acquired
Immunoglobulin G - blood
Immunoglobulin M - blood
Immunoglobulins
Infant
Infections
Infectious diseases
Male
Medicine
Medicine & Public Health
Mortality
Original Article
Pediatrics
Sociodemographics
Turkey
University faculty
Vaccination
Vaccines
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Summary:Vaccination should be timed to take into account the potential interference of maternal antibodies. The purpose of this study was to determine the persistence of maternally acquired antibodies to hepatitis A and varicella zoster in a group of healthy infants between 6 and 24 months of age. These infants were divided into four groups according to the age at the time of follow-up visits. The study group consisted of infants who were brought to the 6-month follow-up visit (group 1, n  = 100), 12-month follow-up visit (group 2, n  = 99), 18-month follow-up visit (group 3, n  = 59), and 24-month follow-up visit (group 4, n  = 59). Hepatitis A, varicella IgG, and IgM antibodies were analyzed qualitatively. Hepatitis A IgG seropositivity was determined as 71 % in group 1, 41.4 % in group 2, 0 % in group 3, and 8.5 % in group 4 ( p   0.05). Conclusion : We found that maternal hepatitis A antibodies in children disappear between 12 and 18 months, whereas maternal varicella antibodies substantially diminish following the sixth month. Therefore, the vaccination timing should be based on factors such as the interference of maternal antibodies, disease susceptibility period, and immune maturation.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-014-2484-2