Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer

Purpose Prostate-specific membrane antigen (PSMA) is a recognized target for imaging prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry results with [ 18 F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate...

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Bibliographic Details
Published in:Molecular imaging and biology 2015-08, Vol.17 (4), p.565-574
Main Authors: Szabo, Zsolt, Mena, Esther, Rowe, Steven P., Plyku, Donika, Nidal, Rosa, Eisenberger, Mario A., Antonarakis, Emmanuel S., Fan, Hong, Dannals, Robert F., Chen, Ying, Mease, Ronnie C., Vranesic, Melin, Bhatnagar, Akrita, Sgouros, George, Cho, Steve Y., Pomper, Martin G.
Format: Article
Language:English
Subjects:
Aged
Antigens, Surface - metabolism
Feasibility Studies
Glutamate Carboxypeptidase II - metabolism
Humans
Imaging
Lysine - adverse effects
Lysine - analogs & derivatives
Lysine - pharmacokinetics
Lysine - therapeutic use
Male
Medicine
Medicine & Public Health
Middle Aged
Positron-Emission Tomography - methods
Prostate - metabolism
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - metabolism
Radiology
Radiometry
Research Article
Tissue Distribution
Urea - adverse effects
Urea - analogs & derivatives
Urea - pharmacokinetics
Urea - therapeutic use
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