The effects of SUUR protein suggest its role in repressive chromatin renewal during replication in Drosophila

Replication of chromosomes is central to heredity. To become available for replication machinery, DNA invariably needs to dissociate from chromatin proteins. Yet, chromatin landscape must be promptly re-established during or soon after replication. Although this process underlies the epigenetic inhe...

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Bibliographic Details
Published in:Nucleus (Austin, Tex.) Tex.), 2015, Vol.6 (4), p.249-253
Main Authors: Posukh, Olga V, Maksimov, Daniil A, Skvortsova, Ksenia N, Koryakov, Dmitry E, Belyakin, Stepan N
Format: Article
Language:English
Subjects:
Animals
chromatin
Chromatin - genetics
Chromatin - metabolism
DNA Replication
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Epigenetic Repression
histone modifications
Histones - genetics
Histones - metabolism
replication
SuUR
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Summary:Replication of chromosomes is central to heredity. To become available for replication machinery, DNA invariably needs to dissociate from chromatin proteins. Yet, chromatin landscape must be promptly re-established during or soon after replication. Although this process underlies the epigenetic inheritance, little is known about its molecular mechanisms. This mini-review is focused on Drosophila melanogaster SUppressor of UnderReplication (SUUR) protein, which is involved both in replication and chromatin maintenance in polytene tissues. Existing data suggest that it is involved in the regulation of chromatin renewal during replication. According to this model, SUUR protein moves along the chromosomes together with the replication complex. When the replication fork enters the repressed, H3K27me3- or H3K9me3-enriched, chromatin, SUUR-containing complex slows down the replisome until these histone modifications are properly placed on the newly-synthesized DNA strands. Suggested model provides an insight into the mechanism of epigenetic information inheritance. This hypothesis could be tested by further analysis of the interplay between local enrichment of repressive histone modifications and the replication fork progression rate.
ISSN:1949-1034
1949-1042
DOI:10.1080/19491034.2015.1074366