Cost-Effectiveness Analysis of Levobupivacaine 0.5 %, a Local Anesthetic, Infusion in the Surgical Wound After Modified Radical Mastectomy

Background and Objective Effective treatment of postoperative pain contributes to decreasing the rate of complications as well as the total cost of the operated patients. The aim of this study was to analyze the costs and the efficiency of use of continuous infusion of levobupivacaine 0.5 % with the...

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Bibliographic Details
Published in:Clinical drug investigation 2015-09, Vol.35 (9), p.575-582
Main Authors: Ferreira Laso, Lourdes, López Picado, Amanda, Antoñanzas Villar, Fernando, Lamata de la Orden, Laura, Ceballos Garcia, Mar, Ibañez López, Carolina, Pipaon Ruilope, Lorena, Lamata Hernandez, Felix, Valero Martinez, Cesar, Aizpuru, Felipe, Hernandez Chaves, Roberto
Format: Article
Language:English
Subjects:
Anesthetics, Local - administration & dosage
Anesthetics, Local - economics
Bupivacaine - administration & dosage
Bupivacaine - analogs & derivatives
Bupivacaine - economics
Cost-Benefit Analysis
Double-Blind Method
Female
Humans
Internal Medicine
Mastectomy, Modified Radical - methods
Medicine
Medicine & Public Health
Original Research Article
Pain, Postoperative - drug therapy
Pain, Postoperative - economics
Pharmacology/Toxicology
Pharmacotherapy
Randomized Controlled Trials as Topic
Treatment Outcome
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Summary:Background and Objective Effective treatment of postoperative pain contributes to decreasing the rate of complications as well as the total cost of the operated patients. The aim of this study was to analyze the costs and the efficiency of use of continuous infusion of levobupivacaine 0.5 % with the help of an infusion pump in modified radical mastectomy. Methods A cost calculation of the analgesic procedures (continuous infusion of levobupivacaine 0.5 % [levobupivacaine group (LG)] or saline [saline group (SG)] (2 ml/h 48 h) has been carried out based on the data of a previous clinical trial (double-blind randomized study) of patients who underwent modified radical mastectomy surgery. The measure of the effectiveness was the point reduction of pain derived from the verbal numeric rating scale (VNRS). The usual incremental cost-effectiveness ratio (ICER) was performed. Results Considering only the intravenous analgesia, overall costs were lower in LG, as less analgesia was used (EUR14.06 ± 7.89 vs. 27.47 ± 14.79; p  
ISSN:1173-2563
1179-1918
DOI:10.1007/s40261-015-0316-4