No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood

Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 1998-12, Vol.420 (1), p.33-36
Main Authors: Léonard, A, Léonard, E.D, Gerber, G.B, Crutzen-Fayt, M.C, Richard, F, Gueulette, J.G, Akhmatullina, N.B
Format: Article
Language:English
Subjects:
Adaptive response
Biological and medical sciences
Biological effects of radiation
Chromosome aberration
Clastogenic factor
Fundamental and applied biological sciences. Psychology
Ionizing radiations
Radiation
Tissues, organs and organisms biophysics
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Summary:Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(98)00144-2