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Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma
Highlights • A total of 998 DEGs and 160 differentially expressed lncRNAs were screened out • FTH1P3, PDIA3F and GTF2IRD2P1 targeted most of DEGs in co-expression network • Up-regulated candidate targets were mainly involved in inflammation-related functions • Up-regulated target genes were signific...
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| Published in: | Archives of oral biology 2015-10, Vol.60 (10), p.1581-1587 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c432t-bc0331e545026cec50b91d6211246c0515197819d93531fc98f24546648c8bb13 |
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| cites | cdi_FETCH-LOGICAL-c432t-bc0331e545026cec50b91d6211246c0515197819d93531fc98f24546648c8bb13 |
| container_end_page | 1587 |
| container_issue | 10 |
| container_start_page | 1581 |
| container_title | Archives of oral biology |
| container_volume | 60 |
| creator | Zhang, Shanchuan, MD Tian, Lili, MD Ma, Penghua, MD Sun, Qiang, MD Zhang, Kai, MD GuanchaoWang, MD Liu, Hongchen, MD Xu, Baohua, MD |
| description | Highlights • A total of 998 DEGs and 160 differentially expressed lncRNAs were screened out • FTH1P3, PDIA3F and GTF2IRD2P1 targeted most of DEGs in co-expression network • Up-regulated candidate targets were mainly involved in inflammation-related functions • Up-regulated target genes were significantly enriched in Toll-like receptor pathway. |
| doi_str_mv | 10.1016/j.archoralbio.2015.08.003 |
| format | article |
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Tian, Lili, MD ; Ma, Penghua, MD ; Sun, Qiang, MD ; Zhang, Kai, MD ; GuanchaoWang, MD ; Liu, Hongchen, MD ; Xu, Baohua, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-bc0331e545026cec50b91d6211246c0515197819d93531fc98f24546648c8bb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Advanced Basic Science</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>co-expression network</topic><topic>Computational Biology</topic><topic>Dentistry</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Regulatory Networks</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Humans</topic><topic>Interleukin-8</topic><topic>long non-coding RNA</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>oral squamous cell carcinoma</topic><topic>RNA, Long Noncoding - biosynthesis</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shanchuan, MD</creatorcontrib><creatorcontrib>Tian, Lili, MD</creatorcontrib><creatorcontrib>Ma, Penghua, MD</creatorcontrib><creatorcontrib>Sun, Qiang, MD</creatorcontrib><creatorcontrib>Zhang, Kai, MD</creatorcontrib><creatorcontrib>GuanchaoWang, MD</creatorcontrib><creatorcontrib>Liu, Hongchen, MD</creatorcontrib><creatorcontrib>Xu, Baohua, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shanchuan, MD</au><au>Tian, Lili, MD</au><au>Ma, Penghua, MD</au><au>Sun, Qiang, MD</au><au>Zhang, Kai, MD</au><au>GuanchaoWang, MD</au><au>Liu, Hongchen, MD</au><au>Xu, Baohua, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>60</volume><issue>10</issue><spage>1581</spage><epage>1587</epage><pages>1581-1587</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Highlights • A total of 998 DEGs and 160 differentially expressed lncRNAs were screened out • FTH1P3, PDIA3F and GTF2IRD2P1 targeted most of DEGs in co-expression network • Up-regulated candidate targets were mainly involved in inflammation-related functions • Up-regulated target genes were significantly enriched in Toll-like receptor pathway.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26276270</pmid><doi>10.1016/j.archoralbio.2015.08.003</doi><tpages>7</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2015-10, Vol.60 (10), p.1581-1587 |
| issn | 0003-9969 1879-1506 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Advanced Basic Science Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism co-expression network Computational Biology Dentistry Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Interleukin-8 long non-coding RNA Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Oligonucleotide Array Sequence Analysis oral squamous cell carcinoma RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Squamous Cell Carcinoma of Head and Neck Up-Regulation |
| title | Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma |
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