Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999-2011

Monitoring antiretroviral drug resistance can inform treatment recommendations; however, there are few such data from US patients before they initiate ART. We analysed data from HIV Outpatient Study (HOPS) participants from nine US HIV clinics who were diagnosed with HIV infection during 1999-2011....

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2015-08, Vol.70 (8), p.2337-2346
Main Authors: Buchacz, Kate, Young, Benjamin, Palella, Jr, Frank J, Armon, Carl, Brooks, John T
Format: Article
Language:English
Subjects:
Adult
Aged
Antiretroviral drugs
Disease transmission
Drug resistance
Drug Resistance, Viral
Epidemiology
Female
Genotype & phenotype
Genotyping Techniques - methods
Genotyping Techniques - utilization
HIV
HIV - genetics
HIV - isolation & purification
HIV Infections - virology
Human immunodeficiency virus
Humans
Infections
Longitudinal Studies
Male
Microbial Sensitivity Tests - methods
Microbial Sensitivity Tests - utilization
Middle Aged
Mutation
Outpatients
Prospective Studies
United States
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Summary:Monitoring antiretroviral drug resistance can inform treatment recommendations; however, there are few such data from US patients before they initiate ART. We analysed data from HIV Outpatient Study (HOPS) participants from nine US HIV clinics who were diagnosed with HIV infection during 1999-2011. Using the IAS-USA December 2010 guidelines, we assessed the frequency of major drug resistance mutations (mDRMs) related to antiretroviral agents in viral isolates from patients who underwent commercial genotypic testing (GT) for resistance before initiating ART. We employed general linear regression models to assess factors associated with having undergone GT, and then factors associated with having mDRM. Among 1531 eligible patients, 758 (49.5%) underwent GT before first ART, increasing from 15.5% in 1999-2002 to 75.9% in 2009-11 (P 5.0 log10 copies/mL and those with a first HOPS visit in 2006 or later were significantly (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkv120