Loading…

Application of RDC enhanced NMR spectroscopy in structural analysis of thiacalix[4]arene derivatives

Thiacalix[4]arene spirodienone was rearranged into the corresponding phenoxathiin-based macrocycle. Alkylation of this inherently chiral system to achieve its immobilization led to a mixture of only two (out of four theoretically possible) stereoisomers. As standard NOE and dynamic NMR experiments d...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-10, Vol.13 (37), p.9610-9618
Main Authors: Vrzal, L, Kratochvílová-Šimánová, M, Landovský, T, Polívková, K, Budka, J, Dvořáková, H, Lhoták, P
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thiacalix[4]arene spirodienone was rearranged into the corresponding phenoxathiin-based macrocycle. Alkylation of this inherently chiral system to achieve its immobilization led to a mixture of only two (out of four theoretically possible) stereoisomers. As standard NOE and dynamic NMR experiments did not lead to unambiguous determination of the structures we applied the Residual Dipolar Coupling constant (RDC) method. Poly-γ-ethyl-l-glutamate (PELG) and poly-γ-benzyl-l-glutamate (PBLG) were found to be easily applicable lyotropic liquid crystalline alignment media for the conformational analysis of thiacalixarene derivatives. Using these media the 1,2-alternate and the partial cone conformations were determined unequivocally.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01424g