Reproductive outcome in offspring of parents occupationally exposed to lead in Norway

In Norway, great efforts have been made to protect both male and female employees against teratogenic exposures. Associations between occupational lead exposure and reproductive outcome in the offspring were studied. All births in Norway 1970–1993 with possible maternal or paternal occupational lead...

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Bibliographic Details
Published in:American journal of industrial medicine 1998-11, Vol.34 (5), p.431-437
Main Authors: Irgens, Ågot, Krüger, Kirsti, Skorve, Anne H., Irgens, Lorentz M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
birth defect
Birth Weight
Chemical and industrial products toxicology. Toxic occupational diseases
Congenital Abnormalities - etiology
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gestational Age
human
Humans
Lead
Male
Maternal Exposure
Medical sciences
Metals and various inorganic compounds
Norway
occupation
Occupational Exposure
offspring
Paternal Exposure
Pregnancy
Pregnancy Outcome
reproductive outcome
Teratology. Teratogens
Toxicology
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Summary:In Norway, great efforts have been made to protect both male and female employees against teratogenic exposures. Associations between occupational lead exposure and reproductive outcome in the offspring were studied. All births in Norway 1970–1993 with possible maternal or paternal occupational lead exposure were compared with a reference population of offspring of parents without occupational lead exposure. Offspring of lead exposed mothers had an increased risk of low birth weight (RR = 1.34; CI = 1.12–1.60) and neural tube defects (RR = 2.87; CI = 1.05–6.38). Effects on birth weight and gestational age showed significant dose‐response associations. Offspring of lead exposed fathers had no increased risks of any of the analyzed reproductive outcomes. However, decreased risks were observed of low birth weight (RR = 0.91; CI = 0.86–0.96) and preterm birth (RR = 0.89; CI = 0.86–0.93). Further efforts seem to be needed to protect the offspring of lead‐exposed mothers. Am. J. Ind. Med. 34:431–437, 1998. © 1998 Wiley‐Liss, Inc.
ISSN:0271-3586
1097-0274
DOI:10.1002/(SICI)1097-0274(199811)34:5<431::AID-AJIM3>3.0.CO;2-T