Contribution of acoustic radiation force impulse (ARFI) elastography to the ultrasound diagnosis of biliary atresia

Background Children with biliary atresia rapidly develop liver fibrosis secondary to inflammatory destruction of the biliary tract. Noninvasive detection of liver fibrosis in neonatal/infantile cholestasis is an additional criterion for the diagnosis of biliary atresia, leading to prompt surgical ex...

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Bibliographic Details
Published in:Pediatric radiology 2015-09, Vol.45 (10), p.1489-1495
Main Authors: Hanquinet, Sylviane, Courvoisier, Delphine S., Rougemont, Anne-Laure, Dhouib, Amira, Rubbia-Brandt, Laura, Wildhaber, Barbara E., Merlini, Laura, McLin, Valerie A., Anooshiravani, Mehrak
Format: Article
Language:English
Subjects:
Bile Ducts - diagnostic imaging
Biliary Atresia - complications
Biliary Atresia - diagnostic imaging
Elasticity Imaging Techniques
Female
Humans
Imaging
Infant
Infant, Newborn
Liver - diagnostic imaging
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Male
Medicine
Medicine & Public Health
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Pediatrics
Radiology
Reproducibility of Results
Retrospective Studies
Severity of Illness Index
Ultrasound
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Summary:Background Children with biliary atresia rapidly develop liver fibrosis secondary to inflammatory destruction of the biliary tract. Noninvasive detection of liver fibrosis in neonatal/infantile cholestasis is an additional criterion for the diagnosis of biliary atresia, leading to prompt surgical exploration. Objective To assess the value of US with acoustic radiation force impulse (ARFI) elastography to detect biliary atresia in the workup of neonatal/infantile cholestasis. Materials and methods In this retrospective study, 20 children with cholestasis suspected of having biliary atresia were investigated by US and ARFI. We evaluated the association between US findings and the diagnosis of biliary atresia and with two scores of liver fibrosis obtained from liver biopsy. Results In univariate analyses, gallbladder size, triangular cord sign, spleen size and ARFI values were found to be associated with biliary atresia, though only the triangular cord sign remained significant when elevated gamma glutamyltransferase (GGT) was included as a predictor. In contrast, spleen size and ARFI correlated with the degree of liver fibrosis on biopsy ( r  > 0.70, P  
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-015-3352-6