Dose-dependence Of Caffeine Supplementation On Cycling Performance

This study examined the effect of caffeine supplementation at two different dosages (3 and 6 mg/kg body weight) on a 40-km cycling time trial. We further sought to obtain initial data on whether the CYP1A2 polymorphism influenced the response at both a lower and high caffeine dose. 16 male cyclists...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.719-719
Main Authors: Martin, Michael, Luden, Nicholas D, Klein, Courtney S, Saunders, Michael J, Bechtel, Marta K, Dunham, Wade, Hancock, Melyssa, Womack, Christopher J
Format: Article
Language:English
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Summary:This study examined the effect of caffeine supplementation at two different dosages (3 and 6 mg/kg body weight) on a 40-km cycling time trial. We further sought to obtain initial data on whether the CYP1A2 polymorphism influenced the response at both a lower and high caffeine dose. 16 male cyclists (Ht = 176.6 + or - 6.8 cm, Wt = 71.8 + or - 7.8 kg, VO2max = 64.7 + or - 9.1 ml/kg/min) completed three separate computer-simulated 40-km cycling time trials one hour after the ingestion of 3 mg/kg caffeine, 6 mg/kg caffeine and a placebo. Subjects were genotyped for the polymorphism of the CYP1A2 gene and classified as AA homozygotes (N=6) or C allele carriers (N=10). There was a main effect for treatment whereby both doses of caffeine significantly (P < 0.05) improved 40-km time (Placebo = 74.1 + or - 5.4 min, 3 mg/kg = 72.7 + or - 4.6 min, 6 mg/kg = 71.6 + or - 4.7 min).
ISSN:0195-9131