The Effects of Endurance Training and Different Methionine-contained Diets on Insulin/IGF-1 System in Skeletal Muscle

To investigate the effects of different methionine (M)-contained diets combined with endurance exercise (E) training on insulin/IGF-1 system in skeletal muscles. Male Sprague Dawley rats (7 weeks old, n=72) were randomly assigned to six groups, which were the 0.86%M, 0.52%M, 0.17%M, 0.86%M+E, 0.52%M...

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Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.445-445
Main Authors: Liang, Young-Yu, Chang, Hsin-wen, Kuo, Liang-Tong, Hsieh, Sandy S, Chang, Ming-Shin, Huang, Tsang-Hai
Format: Article
Language:English
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Summary:To investigate the effects of different methionine (M)-contained diets combined with endurance exercise (E) training on insulin/IGF-1 system in skeletal muscles. Male Sprague Dawley rats (7 weeks old, n=72) were randomly assigned to six groups, which were the 0.86%M, 0.52%M, 0.17%M, 0.86%M+E, 0.52%M+E, and 0.17%M+E groups (n=12 for each group). Serum TBARS, insulin, insulin-like growth factor-binding protein-3(IGFBP-3), IGF-1/IGFBP-3 ratio reached the significant level both in the main effects of diet and exercise. Skeletal muscle markers, IGF-1 receptor (IGF-1R), insulin receptor (IR) all reached the significant level in the main effect of exercise. The results of post hoc comparison were 1) IGF-1R (E: 0.01+ or -0.05% < non-E: 1.15+ or -0.04%; 2) IR: (E: 0.91+ or -0.04%, non-E 1.18+ or -0.04%).
ISSN:0195-9131