First Analysis of Mortality and Occupational Radiation Exposure based on the National Dose Registry of Canada

A cohort mortality study of occupational radiation exposure was conducted using the records of the National Dose Registry of Canada. The cohort consisted of 206,620 individuals monitored for radiation exposure between 1951 and 1983 with mortality follow-up through December 31, 1987. A total of 5,426...

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Bibliographic Details
Published in:American journal of epidemiology 1998-09, Vol.148 (6), p.564-574
Main Authors: Ashmore, J. P., Krewski, D., Zielinski, J. M., Jiang, H., Semenciw, R., Band, P. R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Canada - epidemiology
Chemical, physic and infectious diseases
Female
Humans
ionizing
leukemia
Leukemia, Radiation-Induced - mortality
Male
Medical sciences
Middle Aged
mortality
neoplasms
Neoplasms, Radiation-Induced - mortality
occupational exposure
Occupational Exposure - adverse effects
Occupational medicine
Odds Ratio
Physic and infectious agents
Public health. Hygiene-occupational medicine
radiation
Radiation Dosage
Radiation Injuries - etiology
Radiation Injuries - mortality
radiation-induced
Registries
Risk
Sex Distribution
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Summary:A cohort mortality study of occupational radiation exposure was conducted using the records of the National Dose Registry of Canada. The cohort consisted of 206,620 individuals monitored for radiation exposure between 1951 and 1983 with mortality follow-up through December 31, 1987. A total of 5,426 deaths were identified by computerized record linkage with the Canadian Mortality Data Base. The standardized mortality ratio for all causes of death was 0.61 for both sexes combined. However, trends of increasing mortality with cumulative exposure to whole body radiation were noted for all causes of death in both males and females. In males, cancer mortality appeared to increase with cumulative exposure to radiation, without any clear relation to specific cancers. Unexplained trends of increasing mortality due to cardiovascular diseases (males and females) and accidents (males only) were also noted. The excess relative risk for both sexes, estimated to be 3.0% per 10 mSv (90% confidence interval 1.1–4.8) for all cancers combined, is within the range of risk estimates previously reported in the literature. Am J Epidemiol 1998;148:564–74.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a009682