Should patients with ALS gain weight during their follow-up?

Abstract It was recently postulated that a nutritional intervention aiming at achieving weight gain might increase survival in ALS patients. This article discusses the effect of nutritional status and weight gain on survival, respiratory status and physical function. Based on the available literatur...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-11, Vol.31 (11), p.1368-1371
Main Authors: Héritier, Anne-Chantal, M.D, Janssens, Jean-Paul, M.D, Adler, Dan, M.D, Ferfoglia, Ruxandra Iancu, M.D, Genton, Laurence, M.D
Format: Article
Language:English
Subjects:
Activities of Daily Living
ALS
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - mortality
Body composition
Body Mass Index
Body weight
Fat mass
Fat-free mass
Gastroenterology and Hepatology
Humans
Mortality
Muscle Strength
Nutrition
Nutritional Status
Obesity - complications
Paresis - etiology
Patients
Respiration
Respiratory function
Studies
Thinness - complications
Thinness - diet therapy
Weight
Weight Gain
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Summary:Abstract It was recently postulated that a nutritional intervention aiming at achieving weight gain might increase survival in ALS patients. This article discusses the effect of nutritional status and weight gain on survival, respiratory status and physical function. Based on the available literature, it remains unknown whether weight gain during the progression of the disease improves survival whatever the baseline body weight is. A high body mass index may impair respiratory muscle function and passive mobilization of paretic patients. Future research should evaluate the effect of changes in weight and body composition on clinical outcome while taking into account respiratory muscle strength and physical function.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2015.06.005