Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort

Knowledge about course of illness can help clinicians to develop effective interventions and improve treatment outcomes. The goal of this study was to construct positive and negative symptom trajectories based on structured clinical assessments collected over 10years within a cohort of people with f...

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Bibliographic Details
Published in:Schizophrenia research 2015-10, Vol.168 (1-2), p.84-91
Main Authors: Austin, Stephen F., Mors, Ole, Budtz-Jørgensen, Esben, Secher, Rikke Gry, Hjorthøj, Carsten R., Bertelsen, Mette, Jeppesen, Pia, Petersen, Lone, Thorup, Anne, Nordentoft, Merete
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Course of illness
Female
Humans
Logistic Models
Male
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychotic Disorders - physiopathology
Psychotic Disorders - psychology
Schizophrenia
Symptom trajectories
Young Adult
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Summary:Knowledge about course of illness can help clinicians to develop effective interventions and improve treatment outcomes. The goal of this study was to construct positive and negative symptom trajectories based on structured clinical assessments collected over 10years within a cohort of people with first episode psychosis. A cohort of 496 people with first episode psychosis (ICD-10, F20-28) originally recruited for the OPUS study (1998–2000) and treated in community psychiatric services were rated on clinical symptoms at 5 different occasions across ten years. Psychopathology was assessed using the Scales for Assessment of Positive and Negative Symptoms. Symptom trajectories were constructed using Latent Class Analysis. Five distinct trajectories were identified for positive symptoms (response — 47%, delayed response — 12%, relapse — 15%, non-response — 13% and episodic response — 13%). Four distinct trajectories were identified for negative symptoms (response — 28%, delayed response — 19%, relapse — 26% and non-response — 27%). Multivariable regression analysis of baseline characteristics identified that longer duration of untreated psychosis (OR 1.27–1.47, p
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2015.07.021