Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resis...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2015-09, Vol.7 (9), p.664-672
Main Authors: Yanai, Hagai, Shteinberg, Albert, Porat, Ziv, Budovsky, Arie, Braiman, Alex, Zeische, Rolf, Fraifeld, Vadim E.
Format: Article
Language:English
Subjects:
Actins - biosynthesis
Actins - genetics
Aged
beta-Galactosidase - metabolism
Cell Division
Cell Proliferation
Cell Survival
Cells, Cultured
Cellular Senescence
Disease Progression
Fibroblasts - pathology
Humans
Lung - pathology
Middle Aged
Oxidative Stress
Pulmonary Fibrosis - pathology
Research Paper
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