Evaluation of light-emitting diodes (LED) effect on skin biology (in vitro study)

Background Interest in anti‐aging approaches has grown significantly in recent years. The most popular are the non invasive methods to decrease the signs of aging. One such method is LED‐based therapy. Methods This study investigated the potential of two different wavelengths, 590 nm and 630 nm, com...

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Bibliographic Details
Published in:Skin research and technology 2015-11, Vol.21 (4), p.426-436
Main Authors: Chabert, R., Fouque, L., Pinacolo, S., Garcia-Gimenez, N., Bonnans, M., Cucumel, K., Domloge, N.
Format: Article
Language:English
Subjects:
Cell Survival - physiology
Cell Survival - radiation effects
Cells, Cultured
chronological aging reverse
cumulative wavelengths
Dose-Response Relationship, Radiation
Equipment Design
Equipment Failure Analysis
healing process
Humans
Keratinocytes - cytology
Keratinocytes - physiology
Keratinocytes - radiation effects
Light
light-emitted diodes
Lighting - instrumentation
Lighting - methods
proliferation
Radiation Dosage
Semiconductors
Skin - cytology
Skin - radiation effects
Skin Physiological Phenomena - radiation effects
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Summary:Background Interest in anti‐aging approaches has grown significantly in recent years. The most popular are the non invasive methods to decrease the signs of aging. One such method is LED‐based therapy. Methods This study investigated the potential of two different wavelengths, 590 nm and 630 nm, combined or not, in the photobiomodulation of proteins involved in the slowdown of the skin aging. Results These in vitro results on cell viability, cell shape, and mitochondrial function support and build on previous studies suggested that LED treatment is safe. Regarding its biological functions, our data indicated that the combination of two different wavelengths acted in synergy to enhance the impact of each irradiation alone. Combined, the LED wavelengths could improve in vitro the cell shape, the cell proliferation, and the level of major proteins involved in the healing process. Conclusion These benefits may lead to reinforcement of the skin organization and structure. This hypothesis will be checked in future clinical studies.
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.12210