Wound healing complications in brain tumor patients on Bevacizumab

• Published in: Journal of neuro-oncology 2015-09, Vol.124 (3), p.501-506
• Main Authors: Ladha, Harshad, Pawar, Tushar, Gilbert, Mark R., Mandel, Jacob, O-Brien, Barbara, Conrad, Charles, Fields, Margaret, Hanna, Teresa, Loch, Carolyn, Armstrong, Terri S.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors - therapeutic use; Bevacizumab - therapeutic use; Brain Neoplasms - drug therapy; Clinical Study; Electronic Health Records - statistics & numerical data; Female; Follow-Up Studies; Glioblastoma - drug therapy; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Oncology; Retrospective Studies; Treatment Outcome; Wound Healing - drug effects; Young Adult
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/s11060-015-1868-0

Bevacizumab (BEV) is commonly used for treating recurrent glioblastoma (GBM), and wound healing is a well-established adverse event. Retrospective analysis of GBM patients with and without wound healing complications while on BEV treatment is reported. 287 patients identified, majority were males (60 %) with median age of 52.5 years. 14 cases identified with wound healing problems, related to either craniotomy (n = 8) or other soft tissue wounds (n = 6). Median duration of BEV treatment to complication was 62 days (range 6–559). Majority received 10 mg/kg (n = 11) and nine (64.3 %) were on corticosteroids, with median daily dose of 6 mg (range 1–16 mg) for median of 473 days before starting BEV. For dehisced craniotomy wounds, median time for starting BEV from last surgery was 29 days (range 27–345). Median time from starting BEV to developing wound complication was 47 days (range 16–173). Seven (87.5 %) had infected wounds requiring antibiotics, hospitalization. Four (50 %) required plastic surgery. BEV stopped and safely resumed in 6 (75 %) patients; median delay was 70 days (range 34–346). Soft tissue wounds included decubitus ulcer, dehisced striae, herpes simplex, trauma to hand and back, and abscess. Median time from starting BEV to wound issues was 72 days (range 6–559). Five (83.3 %) were infected, requiring antibiotics. While three (50 %) required hospitalization, none required plastic surgery. Treatment stopped in five (83.3 %) and restarted in two (median delay 48 days, range 26–69). Wound healing complications are uncommon but associated with significant morbidity. Identifying those at risk and contributing factors warrants further investigation.