Caffeine delays autonomic recovery following acute exercise

Background Impaired autonomic recovery of heart rate (HR) following exercise is associated with an increased risk of sudden death. Caffeine, a potent stimulator of catecholamine release, has been shown to augment blood pressure (BP) and sympathetic nerve activity; however, whether caffeine alters au...

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Bibliographic Details
Published in:European journal of preventive cardiology 2015-11, Vol.22 (11), p.1473-1479
Main Authors: Bunsawat, Kanokwan, White, Daniel W, Kappus, Rebecca M, Baynard, Tracy
Format: Article
Language:English
Subjects:
Adult
Arterial Pressure - drug effects
Autonomic Nervous System - drug effects
Autonomic Nervous System - physiology
Baroreflex - drug effects
Caffeine - administration & dosage
Chicago
Cross-Over Studies
Double-Blind Method
Exercise
Female
Healthy Volunteers
Heart - innervation
Heart Rate - drug effects
Humans
Male
Recovery of Function
Time Factors
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Summary:Background Impaired autonomic recovery of heart rate (HR) following exercise is associated with an increased risk of sudden death. Caffeine, a potent stimulator of catecholamine release, has been shown to augment blood pressure (BP) and sympathetic nerve activity; however, whether caffeine alters autonomic function after a bout of exercise bout remains unclear. Methods In a randomized, crossover study, 18 healthy individuals (26 ± 1 years; 23.9 ± 0.8 kg·m−2) ingested caffeine (400 mg) or placebo pills, followed by a maximal treadmill test to exhaustion. Autonomic function and ventricular depolarization/repolarization were determined using heart rate variability (HRV) and corrected QT interval (QTc), respectively, at baseline, 5, 15, and 30 minutes post-exercise. Results Maximal HR (HRmax) was greater with caffeine (192 ± 2 vs. 190 ± 2 beat·min−1, p 
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487314554867