Peroxynitrite Uncloaked?

The nitration of tyrosine in vivo by peroxynitrite causes a kinetic problem: nitration, which is first-order in peroxynitrite and zeroth-order in tyrosine, takes place at the rate of decay of peroxynitrite, which is approximately 1.0 s super(-1) at 37 degree C and pH 7.4, while in a cell peroxynitri...

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Bibliographic Details
Published in:Chemical research in toxicology 1998-07, Vol.11 (7), p.716-717
Main Author: Koppenol, Willem H
Format: Article
Language:English
Subjects:
Free Radicals - chemistry
Hydrogen-Ion Concentration
Isomerism
Kinetics
Nitrates - chemistry
Oxidants - chemistry
Tyrosine - chemistry
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Summary:The nitration of tyrosine in vivo by peroxynitrite causes a kinetic problem: nitration, which is first-order in peroxynitrite and zeroth-order in tyrosine, takes place at the rate of decay of peroxynitrite, which is approximately 1.0 s super(-1) at 37 degree C and pH 7.4, while in a cell peroxynitrite disappears much faster through the bimolecular reaction with sulfhydryls. The rate of this process is estimated as follows: the product of an average rate constant of 4 x 10 super(3) M super(-1) s super(-1) under the same conditions and a cellular concentration of approximately 5-10 mM yields a rate of disappearance of 20-40 s super(-1).
ISSN:0893-228X
1520-5010
DOI:10.1021/tx9800607