Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands

Background & Aims Effectiveness of surveillance for hepatocellular carcinoma is controversial. We here explore its effects in “real life” clinical practice. Methods Patients with hepatocellular carcinoma diagnosed in the period 2005–2012 in five Dutch academic centers were evaluated. Surveillanc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hepatology 2015-11, Vol.63 (5), p.1156-1163
Main Authors: van Meer, Suzanne, de Man, Robert A, Coenraad, Minneke J, Sprengers, Dave, van Nieuwkerk, Karin M.J, Klümpen, Heinz-Josef, Jansen, Peter L.M, IJzermans, Jan N.M, van Oijen, Martijn G.H, Siersema, Peter D, van Erpecum, Karel J
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - epidemiology
Female
Follow-Up Studies
Gastroenterology and Hepatology
Hepatocellular carcinoma
Humans
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Male
Middle Aged
Morbidity - trends
Neoplasm Staging
Netherlands - epidemiology
Population Surveillance - methods
Retrospective Studies
Risk Assessment
Surveillance
Survival
Survival Rate - trends
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background & Aims Effectiveness of surveillance for hepatocellular carcinoma is controversial. We here explore its effects in “real life” clinical practice. Methods Patients with hepatocellular carcinoma diagnosed in the period 2005–2012 in five Dutch academic centers were evaluated. Surveillance was defined as ⩾2 screening tests during three preceding years and at least one radiologic imaging test within 18 months before diagnosis. Results 295 (27%) of 1074 cases underwent surveillance. Median time interval between last negative radiologic imaging and hepatocellular carcinoma diagnosis was 7.5 months. In the surveillance group, cirrhosis (97% vs . 60%, p 9 months: adjusted HRs 0.51 and 0.50, 95% confidence intervals: 0.39–0.67 and 0.37–0.69). Conclusions Surveillance for hepatocellular carcinoma was associated with smaller tumor size, earlier tumor stage, with an impact on therapeutic strategy and was an independent predictor of survival.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2015.06.012