Case study interpretation: Report from the ICCS Annual Meeting, Seattle, 2014

The Case Study Interpretation (CSI) cases presented at the 2014 International Clinical Cytometry Society (ICCS) meeting in Seattle illustrate the utility of state‐of‐the art multiparameter flow cytometry in the diagnosis of hematolymphoid neoplasms. Download the listmode files (Supporting Informatio...

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Bibliographic Details
Published in:Cytometry. Part B, Clinical cytometry Clinical cytometry, 2015-11, Vol.88 (6), p.413-424
Main Authors: Fromm, Jonathan R., Tagliente, Damian J., Shaver, Aaron C., Neppalli, Vishala, Craig, Fiona E.
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antigens, CD - immunology
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Dendritic Cells - immunology
Dendritic Cells - pathology
Female
Flow Cytometry
Humans
Immunophenotyping
leukemia
Leukemia - diagnosis
Leukemia - immunology
lymphoma
Male
Middle Aged
mixed phenotype
plasmacytoid dendritic
T-Lymphocytes - immunology
T-Lymphocytes - pathology
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Summary:The Case Study Interpretation (CSI) cases presented at the 2014 International Clinical Cytometry Society (ICCS) meeting in Seattle illustrate the utility of state‐of‐the art multiparameter flow cytometry in the diagnosis of hematolymphoid neoplasms. Download the listmode files (Supporting Information) and test your analysis skills before reading the case reports, keeping in mind the following questions. How many separate abnormal mature B‐cell populations can you identify, and how many of these represent different subtypes of B‐cell neoplasm? How many separate abnormal mature T‐cell populations can you identify, and do these represent different subtypes of T‐cell neoplasm or phenotypic heterogeneity in one neoplasm? How many separate immature/blastic cell populations can you identify, and do they meet criteria for mixed phenotype leukemia? Is there a population of blasts that lacks T‐cell, B‐cell, and myeloid lineage defining antigens and if so, what entities should you consider and what additional antigens should you assess for? © 2015 International Clinical Cytometry Society
ISSN:1552-4949
1552-4957
DOI:10.1002/cyto.b.21238