Assessment of muscle tissue oxygen saturation after out-of-hospital cardiac arrest

Abstract Purpose Pathophysiology of cardiac arrest corresponds to an ischemia-reperfusion syndrome with deep impairment of microcirculation. Muscular tissue oxygen saturation (StO2 ) is a noninvasive method of evaluation of microcirculation. Our study was aimed at assessing the prognosis value of mu...

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Bibliographic Details
Published in:Journal of critical care 2015-12, Vol.30 (6), p.1184-1189
Main Authors: Orban, Jean-Christophe, MD, PhD, Scarlatti, Audrey, MD, Danin, Pierre-Eric, MD, Dellamonica, Jean, MD, PhD, Bernardin, Gilles, MD, PhD, Ichai, Carole, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Body temperature
Cardiac arrest
Catheters
Critical Care
Fatalities
Female
Heart attacks
Hospitals
Humans
Hypothermia
Hypothermia, Induced
Male
Medical prognosis
Middle Aged
Out-of-hospital cardiac arrest
Out-of-Hospital Cardiac Arrest - therapy
Outcome
Oxygen - chemistry
Patient Admission
Patients
Physiology
Prognosis
Prospective Studies
Sensitivity and Specificity
Studies
Tissular saturation of oxygen
Treatment Outcome
Young Adult
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Summary:Abstract Purpose Pathophysiology of cardiac arrest corresponds to an ischemia-reperfusion syndrome with deep impairment of microcirculation. Muscular tissue oxygen saturation (StO2 ) is a noninvasive method of evaluation of microcirculation. Our study was aimed at assessing the prognosis value of muscular StO2 in patients admitted for out-of-hospital cardiac arrest (OHCA) and treated with hypothermia. Materials and methods We conducted a prospective bicentric observational study including OHCA patients treated with therapeutic hypothermia. Baseline StO2 , derived variables (desaturation and resaturation slopes), and lactate levels were compared at different times between patients with good and poor outcomes. Prognosis was assessed by the Cerebral Performance Category (CPC) score at 6 months after admission (CPC 1-2, good outcome; CPC 3-5, poor outcome). Results Forty-four patients were included, 17 good and 27 poor outcomes at 6 months. At admission, StO2 and lactate levels were lower in good outcome patients. Desaturation and resaturation slopes did not differ between groups. Conclusions After an OHCA treated with therapeutic hypothermia, StO2 was correlated with outcome. Further research is needed to better understand the pathophysiological process underlying our results.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2015.07.010