Gray matter volumes in patients with bipolar disorder and their first-degree relatives

Abstract Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2015-11, Vol.234 (2), p.188-193
Main Authors: Nery, Fabiano G, Gigante, Alexandre Duarte, Amaral, Jose A, Fernandes, Francy B.F, Berutti, Mariangeles, Almeida, Karla M, Carneiro, Camila de Godoi, Duran, Fabio Luis Souza, Otaduy, Maria G, Leite, Claudia Costa, Busatto, Geraldo, Lafer, Beny
Format: Article
Language:English
Subjects:
Adult
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - genetics
Brain - pathology
Cerebral cortex
Diagnostic and Statistical Manual of Mental Disorders
Endophenotypes
Family
Female
Gray Matter - pathology
Humans
Magnetic Resonance Imaging
Male
Psychiatry
Radiology
Thalamus
Young Adult
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Summary:Abstract Bipolar disorder (BD) is highly heritable. First-degree relatives of BD patient have an increased risk to develop the disease. We investigated abnormalities in gray matter (GM) volumes in healthy first-degree relatives of BD patients to identify possible brain structural endophenotypes for the disorder. 3D T1-weighted magnetic resonance images were obtained from 25 DSM-IV BD type I patients, 23 unaffected relatives, and 27 healthy controls (HC). A voxel-based morphometry protocol was used to compare differences in GM volumes between groups. BD patients presented reduced GM volumes bilaterally in the thalamus compared with HC. Relatives presented no global or regional GM differences compared with HC. Our negative results do not support the role of GM volume abnormalities as endophenotypes for BD. Thalamic volume abnormalities may be associated the pathophysiology of the disease.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2015.09.005