Hypoxic pulmonary vasoconstriction: role of ion channels

Department of Medicine, University of California, San Diego, La Jolla, California Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural changes of the pulmonary vasculature including arterial medial hypertrophy. Electro- and pharmacomechanical mechanisms are involved...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2005-01, Vol.98 (1), p.415-420
Main Authors: Mauban, Joseph R. H, Remillard, Carmelle V, Yuan, Jason X.-J
Format: Article
Language:English
Subjects:
Animals
Calcium - metabolism
Hemostasis
Humans
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - physiopathology
Hypoxia - complications
Hypoxia - physiopathology
Ion Channel Gating
Ion Channels - metabolism
Lung - blood supply
Lung - physiopathology
Models, Biological
Oxygen - metabolism
Pulmonary Artery - physiopathology
Vasoconstriction
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Summary:Department of Medicine, University of California, San Diego, La Jolla, California Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural changes of the pulmonary vasculature including arterial medial hypertrophy. Electro- and pharmacomechanical mechanisms are involved in regulating pulmonary vasomotor tone, whereas intracellular Ca 2+ serves as an important signal in regulating contraction and proliferation of pulmonary artery smooth muscle cells. Herein, we provide a basic overview of the cellular mechanisms involved in the development of hypoxic pulmonary vasoconstriction. Our discussion focuses on the roles of ion channels permeable to K + and Ca 2+ , membrane potential, and cytoplasmic Ca 2+ in the development of acute hypoxic pulmonary vasoconstriction and chronic hypoxia-mediated pulmonary vascular remodeling. hypoxia; proliferation; remodeling; calcium Address for reprint requests and other correspondence: J. X.-J. Yuan, Division of Pulmonary and Critical Care Medicine, Dept. of Medicine, Univ. of California, San Diego, 9500 Gilman Dr., MC 0725, La Jolla, CA 92093-0725 (E-mail: xiyuan{at}ucsd.edu )
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00732.2004