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Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia
Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR low/neg ) in bone...
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| Published in: | International journal of hematology 2015-11, Vol.102 (5), p.579-586 |
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| cites | cdi_FETCH-LOGICAL-c466t-15ea3ada482c4ab80e42c445b592d3166071183048f06b17982cae06502fb8123 |
| container_end_page | 586 |
| container_issue | 5 |
| container_start_page | 579 |
| container_title | International journal of hematology |
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| creator | Sun, Hui Li, Yi Zhang, Zhi-fen Ju, Ying Li, Li Zhang, Bing-chang Liu, Bin |
| description | Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR
low/neg
) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs |
| doi_str_mv | 10.1007/s12185-015-1865-2 |
| format | article |
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low/neg
) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs < 1500 group were 72.73 and 81.25 %, respectively. No significant differences were found between the two groups. MDSC levels in the complete remission group were significantly decreased after chemotherapy, while in the partial remission and non-remission groups, there were no significant differences. The level of MDSCs in the high minimal residual disease (MRD) group was significantly higher than that in the middle and low MRD groups. High levels of Wilms’ Tumor-1 (WT-1) protein were strongly correlated with higher bone marrow MDSC levels. In conclusion, we report here a population of immunosuppressive monocytes in the bone marrow of patients with AML characterized by the CD33
high
CD11b + HLA-DR
low/neg
phenotype. These cells appear to impact the clinical course and prognosis of AML. This data may provide potentially important targets for novel therapies.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-015-1865-2</identifier><identifier>PMID: 26358057</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Bone Marrow Cells - immunology ; Bone Marrow Cells - metabolism ; Bone Marrow Cells - pathology ; Female ; Fibrin Fibrinogen Degradation Products - immunology ; Fibrin Fibrinogen Degradation Products - metabolism ; Hematology ; Humans ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - immunology ; Leukemia, Myeloid, Acute - metabolism ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - therapy ; Male ; Medicine ; Medicine & Public Health ; Monocytes - immunology ; Monocytes - metabolism ; Monocytes - pathology ; Neoplasm, Residual ; Oncology ; Original Article ; Prognosis ; Tumor Escape ; WT1 Proteins - blood ; WT1 Proteins - immunology</subject><ispartof>International journal of hematology, 2015-11, Vol.102 (5), p.579-586</ispartof><rights>The Japanese Society of Hematology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-15ea3ada482c4ab80e42c445b592d3166071183048f06b17982cae06502fb8123</citedby><cites>FETCH-LOGICAL-c466t-15ea3ada482c4ab80e42c445b592d3166071183048f06b17982cae06502fb8123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26358057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Hui</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Zhang, Zhi-fen</creatorcontrib><creatorcontrib>Ju, Ying</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zhang, Bing-chang</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><title>Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR
low/neg
) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs < 1500 group were 72.73 and 81.25 %, respectively. No significant differences were found between the two groups. MDSC levels in the complete remission group were significantly decreased after chemotherapy, while in the partial remission and non-remission groups, there were no significant differences. The level of MDSCs in the high minimal residual disease (MRD) group was significantly higher than that in the middle and low MRD groups. High levels of Wilms’ Tumor-1 (WT-1) protein were strongly correlated with higher bone marrow MDSC levels. In conclusion, we report here a population of immunosuppressive monocytes in the bone marrow of patients with AML characterized by the CD33
high
CD11b + HLA-DR
low/neg
phenotype. These cells appear to impact the clinical course and prognosis of AML. This data may provide potentially important targets for novel therapies.</description><subject>Adult</subject><subject>Bone Marrow Cells - immunology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Marrow Cells - pathology</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - immunology</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Hematology</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>Monocytes - pathology</subject><subject>Neoplasm, Residual</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Tumor Escape</subject><subject>WT1 Proteins - blood</subject><subject>WT1 Proteins - immunology</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kd9qFDEUxkNR7Fp9gN6UgDfbi7HnZJLJ7KVs1RZahKrXITM5q2nnzzaZWPoQvrOZbitFEAI5nPzyfSf5GDtEeI8A-iSiwFoVgKrAulKF2GOLh6LUWr5gC1gJVSiNsM9ex3gNgBqkfsX2RVWqGpResN_nQxvIRuJ-4P09daN3haPgf5HjMW23gWIcA2-p6yJfXp5-XcdjbnOv9XbKzJ2ffvLeD763Hc-wdykXzscH0eXl1ekxdzRRO_lxmE2sS93EbZsmejLkHaUb6r19w15ubBfp7eN-wL5_-vhtfVZcfPl8vv5wUbSyqqYCFdnSOitr0Urb1EAyF1I1aiVciVUFGrEuQdYbqBrUq8xZgkqB2DQ1ivKALXe62zDeJoqT6X2cn2gHGlM0qEtRIkilMvruH_R6TGHI081UXtlGZgp3VBvGGANtzDbkHwn3BsHMWZldViZnZeaIzDzE0aNyanpyf288hZMBsQNiPhp-UHhm_V_VP28ann8</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Sun, Hui</creator><creator>Li, Yi</creator><creator>Zhang, Zhi-fen</creator><creator>Ju, Ying</creator><creator>Li, Li</creator><creator>Zhang, Bing-chang</creator><creator>Liu, Bin</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia</title><author>Sun, Hui ; Li, Yi ; Zhang, Zhi-fen ; Ju, Ying ; Li, Li ; Zhang, Bing-chang ; Liu, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-15ea3ada482c4ab80e42c445b592d3166071183048f06b17982cae06502fb8123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Bone Marrow Cells - immunology</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Bone Marrow Cells - pathology</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - immunology</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Hematology</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukemia, Myeloid, Acute - metabolism</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>Monocytes - pathology</topic><topic>Neoplasm, Residual</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Tumor Escape</topic><topic>WT1 Proteins - blood</topic><topic>WT1 Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Hui</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Zhang, Zhi-fen</creatorcontrib><creatorcontrib>Ju, Ying</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zhang, Bing-chang</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Hui</au><au>Li, Yi</au><au>Zhang, Zhi-fen</au><au>Ju, Ying</au><au>Li, Li</au><au>Zhang, Bing-chang</au><au>Liu, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>102</volume><issue>5</issue><spage>579</spage><epage>586</epage><pages>579-586</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR
low/neg
) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs < 1500 group were 72.73 and 81.25 %, respectively. No significant differences were found between the two groups. MDSC levels in the complete remission group were significantly decreased after chemotherapy, while in the partial remission and non-remission groups, there were no significant differences. The level of MDSCs in the high minimal residual disease (MRD) group was significantly higher than that in the middle and low MRD groups. High levels of Wilms’ Tumor-1 (WT-1) protein were strongly correlated with higher bone marrow MDSC levels. In conclusion, we report here a population of immunosuppressive monocytes in the bone marrow of patients with AML characterized by the CD33
high
CD11b + HLA-DR
low/neg
phenotype. These cells appear to impact the clinical course and prognosis of AML. This data may provide potentially important targets for novel therapies.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26358057</pmid><doi>10.1007/s12185-015-1865-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of hematology, 2015-11, Vol.102 (5), p.579-586 |
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| subjects | Adult Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Female Fibrin Fibrinogen Degradation Products - immunology Fibrin Fibrinogen Degradation Products - metabolism Hematology Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Male Medicine Medicine & Public Health Monocytes - immunology Monocytes - metabolism Monocytes - pathology Neoplasm, Residual Oncology Original Article Prognosis Tumor Escape WT1 Proteins - blood WT1 Proteins - immunology |
| title | Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia |
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