Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample—A longitudinal study

Abstract Our aim in this longitudinal study was to evaluate to what extent fat and lean tissue mass variations are associated and can predict RKOA in a large sample of British women followed-up over 10 years. Kellgren/Lawrence (K/L), joint space narrowing (JSN) and osteophyte (OSP) grades were score...

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Bibliographic Details
Published in:Archives of gerontology and geriatrics 2013-01, Vol.56 (1), p.148-154
Main Authors: Blumenfeld, Orit, Williams, Frances M.K, Hart, Deborah J, Arden, Nigel K, Spector, Timothy D, Livshits, Gregory
Format: Article
Language:English
Subjects:
Abdominal fat
Abdominal Fat - anatomy & histology
Abdominal Fat - physiology
Adipose Tissue - anatomy & histology
Adipose Tissue - physiology
Age Factors
BMI
Body fat
Body Mass Index
Composition
Cross-Sectional Studies
DXA
Female
Fitting
Humans
Internal Medicine
Knee Joint - diagnostic imaging
Knees
Lean and fat mass
Leg - anatomy & histology
Leg - physiopathology
Longitudinal Studies
Middle Aged
Osteoarthritis, Knee - diagnostic imaging
Osteophyte - diagnostic imaging
Radiography
RKOA
Women
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Summary:Abstract Our aim in this longitudinal study was to evaluate to what extent fat and lean tissue mass variations are associated and can predict RKOA in a large sample of British women followed-up over 10 years. Kellgren/Lawrence (K/L), joint space narrowing (JSN) and osteophyte (OSP) grades were scored from radiographs of both knees in 909 middle-aged women from the Chingford registry. Body composition components were assessed using the dual energy X-ray absorptiometry (DXA) method. In cross-sectional analysis, combined effect of age, BMI and leg tissue composition was required for best fitting model explaining variations of K/L scoring and osteophytes at lateral compartment. To explain medial osteophytes, age and BMI were sufficient to generate the best fitting model. In prediction analysis, leg lean mass was the more powerful predictor of K/L, medial osteophytes than BMI. In conclusion, BMI appears to influence the development of knee OA through both fat and/or lean mass, depending on RKOA phenotype.
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2012.09.006