Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women

Purpose Serum level of under-carboxylated osteocalcin (ucOC) is considered a sensitive measure of vitamin K status, and ucOC levels are associated with bone mineral density (BMD) and fracture risk in elderly persons. The aim of this study was to assess the relationship between ucOC and BMD in early...

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Bibliographic Details
Published in:European journal of nutrition 2013-02, Vol.52 (1), p.49-55
Main Authors: Emaus, Nina, Nguyen, Nguyen D., Almaas, Bjørg, Berntsen, Gro K., Center, Jacqueline R., Christensen, Monika, Gjesdal, Clara G., Grimsgaard, Anne S., Nguyen, Tuan V., Salomonsen, Laila, Eisman, John A., Fønnebø, Vinjar M.
Format: Article
Language:English
Subjects:
blood serum
Body Height
Body Mass Index
Body Weight
Bone Density
bone metabolism
Chemistry
Chemistry and Materials Science
Double-Blind Method
drug therapy
elderly
Female
femur
Femur Neck - physiology
hips
Humans
lifestyle
lumbar spine
Lumbar Vertebrae - physiology
Menopause
Middle Aged
Norway
Nutrition
Original Contribution
osteocalcin
Osteocalcin - blood
Regression Analysis
risk
Surveys and Questionnaires
vitamin K
Vitamin K - administration & dosage
warfarin
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Summary:Purpose Serum level of under-carboxylated osteocalcin (ucOC) is considered a sensitive measure of vitamin K status, and ucOC levels are associated with bone mineral density (BMD) and fracture risk in elderly persons. The aim of this study was to assess the relationship between ucOC and BMD in early menopausal women. Methods The data reported here come from the enrolment in a double-blinded placebo-controlled randomized trial comprising 334 healthy Norwegian women between 50 and 60 years, 1–5 years after menopause, not using warfarin or medication known to affect bone metabolism. Total hip, femoral neck, lumbar spine, and total body BMD and serum level of ucOC and total osteocalcin were measured, and information of lifestyle was collected through questionnaires. The association between ucOC and BMD at all measurement sites was assessed by multiple regression analyses adjusting for possible confounding variables. Results The absolute serum level of ucOC was significantly and negatively associated with BMD at all measurements sites, both in univariate analyses ( p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-011-0285-1