Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women

• Published in: European journal of nutrition 2013-03, Vol.52 (2), p.717-726
• Main Authors: López-González, Ángel A., Grases, Félix, Monroy, Nieves, Marí, Bartolome, Vicente-Herrero, Mª Teófila, Tur, Fernando, Perelló, Joan
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon - methods; Bone Density; Chemistry; Chemistry and Materials Science; Cross-Sectional Studies; Female; Femur Neck - diagnostic imaging; Humans; Lumbar Vertebrae - diagnostic imaging; Middle Aged; Nutrition; Original Contribution; Osteoporosis, Postmenopausal - diagnostic imaging; Osteoporotic Fractures - diagnostic imaging; Phytic Acid - urine; Risk Assessment; Risk Factors
• ISSN: 1436-6207; 1436-6215
• DOI: 10.1007/s00394-012-0377-6

Introduction The objective of this paper was to evaluate the relationship between urinary concentrations of Ins P 6, bone mass loss and risk fracture in postmenopausal women. Materials and methods A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76–1.42 μM) and 45 high (≥1.42 μM) urinary phytate concentrations. Densitometry values for neck were measured at enrollment and after 12 months (lumbar spine and femoral neck), and 10-year risk fracture was calculated using the tool FRAX ® . Results Individuals with low Ins P 6 levels had significantly greater bone mass loss in the lumbar spine (3.08 ± 0.65 % vs. 0.43 ± 0.55 %) than did those with high phytate levels. Moreover, a significantly greater percentage of women with low than with high Ins P 6 levels showed more than 2 % of bone mass loss in the lumbar spine (55.6 vs. 20.7 %). The 10-year fracture probability was also significantly higher in the low-phytate group compared to the high-phytate group, both in hip (0.37 ± 0.06 % vs 0.18 ± 0.04 %) and major osteoporotic fracture (2.45 ± 0.24 % vs 1.83 ± 0.11 %). Discussion It can be concluded that high urinary phytate concentrations are correlated with reduced bone mass loss in lumbar spine over 12 months and with reduced 10-year probability of hip and major osteoporotic fracture, indicating that increased phytate consumption can prevent development of osteoporosis.