Melatonin—A pleiotropic, orchestrating regulator molecule

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitmen...

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Bibliographic Details
Published in:Progress in neurobiology 2011-03, Vol.93 (3), p.350-384
Main Authors: Hardeland, Rüdiger, Cardinali, Daniel P., Srinivasan, Venkatramanujam, Spence, D. Warren, Brown, Gregory M., Pandi-Perumal, Seithikurippu R.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Binding Sites
biogenesis
central nervous system
circadian rhythm
Circadian Rhythm - physiology
electron transport chain
Energy Metabolism
free radicals
G-protein coupled receptors
Humans
Immune System
inflammation
insulin resistance
ion channels
melatonin
Melatonin - deficiency
Melatonin - physiology
metabolic syndrome
Mitochondria - metabolism
neuroprotective effect
nitric oxide synthase
noninsulin-dependent diabetes mellitus
peripheral nervous system
phosphotransferases (kinases)
pineal body
Pineal Gland - physiology
Receptors, Melatonin - metabolism
Signal Transduction - physiology
sleep
tissues
transcription factors
weight control
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