Prenatal Exposure to Wartime Famine and Development of Antisocial Personality Disorder in Early Adulthood

CONTEXT Several observational epidemiological studies report an association of pregnancy and obstetric complications with development of antisocial personality disorder (ASPD) in offspring. However, the precise nature and timing of the hypothesized biological insults are not known. OBJECTIVE To test...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 1999-08, Vol.282 (5), p.455-462
Main Authors: Neugebauer, Richard, Hoek, Hans Wijbrand, Susser, Ezra
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antisocial personality disorder
Antisocial Personality Disorder - epidemiology
Antisocial Personality Disorder - etiology
Biological and medical sciences
Case studies
Child
Data Collection
Developmental Disabilities - epidemiology
Developmental Disabilities - etiology
Female
Germany
Humans
Male
Malnutrition
Maternal Exposure
Medical sciences
Mental disorders
Netherlands - epidemiology
Personality disorders
Pregnancy
Pregnancy Trimesters
Prenatal development
Prenatal Exposure Delayed Effects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Regression Analysis
Retrospective Studies
Risk Factors
Starvation
Warfare
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Summary:CONTEXT Several observational epidemiological studies report an association of pregnancy and obstetric complications with development of antisocial personality disorder (ASPD) in offspring. However, the precise nature and timing of the hypothesized biological insults are not known. OBJECTIVE To test whether severe maternal nutritional deficiency early in gestation is associated with risk for ASPD in offspring. DESIGN AND SETTING Retrospective cohort study. From October 1944 to May 1945, the German army blockaded food supplies to the Netherlands, subjecting the western Netherlands first to moderate (official food rations, 4200-6300 kJ/d) then to severe (
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.282.5.455