Stress-related changes to immune cells in the skin prior to wounding may impair subsequent healing

Highlights • Young adults with lower stress and faster healing had greater HLA expression in skin. • In younger adults, faster healing was associated with more Langerhans cells in skin. • Older adults with higher perceived stress had fewer macrophages in skin. • Stress affects skin cell immunity and...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.47-51
Main Authors: Koschwanez, Heidi, Vurnek, Maja, Weinman, John, Tarlton, John, Whiting, Christine, Amirapu, Satya, Colgan, Sarah, Long, David, Jarrett, Paul, Broadbent, Elizabeth
Format: Article
Language:English
Subjects:
Activation
Aged
Aged, 80 and over
Allergy and Immunology
Female
HLA
Humans
Immune
Langerhans
Langerhans Cells - immunology
Leukocytes
Macrophages
Macrophages - immunology
Male
Psychiatry
Skin - immunology
Skin - injuries
Skin - pathology
Stress
Stress, Psychological - immunology
Wound healing
Wound Healing - immunology
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Summary:Highlights • Young adults with lower stress and faster healing had greater HLA expression in skin. • In younger adults, faster healing was associated with more Langerhans cells in skin. • Older adults with higher perceived stress had fewer macrophages in skin. • Stress affects skin cell immunity and impacts wound healing speed.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.06.011