Pretreatment with the putative anti-addictive drug, ibogaine, increases the potency of cocaine to elicit locomotor responding : a study with acute and chronic cocaine-treated rats

Results of single-dose studies suggest that the effects of pretreatment with the putative anti-addictive compound, ibogaine, on drug-induced locomotor behavior depends on the previous drug history of the animal. To compare the effects of ibogaine pretreatment on the dose-locomotor response function...

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Bibliographic Details
Published in:Psychopharmacologia 1999-07, Vol.145 (2), p.227-233
Main Authors: SZUMLINSKI, K. K, MAISONNEUVE, I. M, GLICK, S. D
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult and adolescent clinical studies
Animals
Biological and medical sciences
Cocaine
Cocaine - pharmacology
Dose-Response Relationship, Drug
Drug addiction
Drug addictions
Drug dosages
Drug Synergism
Excitatory Amino Acid Antagonists - pharmacology
Female
ibogaine
Ibogaine - pharmacology
Medical sciences
Motor Activity - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Sprague-Dawley
Toxicology
Withdrawal
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Summary:Results of single-dose studies suggest that the effects of pretreatment with the putative anti-addictive compound, ibogaine, on drug-induced locomotor behavior depends on the previous drug history of the animal. To compare the effects of ibogaine pretreatment on the dose-locomotor response function for cocaine in rats treated chronically with either saline or cocaine. Rats were chronically treated with either cocaine (15 mg/kg, IP, once daily for 5 days, followed by 2 week withdrawal) or saline. Ibogaine (40 mg/kg, IP) or vehicle was administered and 19 h later, a cocaine dose-locomotor response test was conducted (0, 5, 10, 20 and 40 mg/kg, IP). Chronic cocaine administration augmented the locomotor response to cocaine in chronic cocaine-treated rats, compared to acutely treated controls. Ibogaine pretreatment enhanced the locomotor effects of cocaine in both chronic and acute cocaine groups. Furthermore, due to the shape of the dose-response curve, in chronic cocaine but not in acute cocaine rats, ibogaine pretreatment enhanced the locomotor response to 5 and 10 mg/kg cocaine while decreasing the locomotor response to 40 mg/kg cocaine. These data demonstrate definitively that ibogaine can enhance sensitivity to the locomotor stimulant effects of cocaine, an effect which depends, in part, on the previous cocaine history of the animal.
ISSN:0033-3158
1432-2072
DOI:10.1007/s002130051053