Cocrystal Formation through Mechanochemistry: from Neat and Liquid-Assisted Grinding to Polymer-Assisted Grinding

Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the established liquid‐assisted grinding (LAG) approach. Polymer‐assisted grinding (POLAG) is demonstrated to provide a new class of catalysts for improvin...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2015-06, Vol.54 (25), p.7371-7375
Main Authors: Hasa, Dritan, Schneider Rauber, Gabriela, Voinovich, Dario, Jones, William
Format: Article
Language:English
Subjects:
Catalysis
Cocrystallization
cocrystals
Crystals
Formations
Mechanochemistry
Particle size
Pathways
polymers
polymorphism
Risk
solid-state reactions
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Summary:Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the established liquid‐assisted grinding (LAG) approach. Polymer‐assisted grinding (POLAG) is demonstrated to provide a new class of catalysts for improving reaction rate and increasing product diversity during mechanochemical cocrystallization reactions. We demonstrate that POLAG provides advantages comparable to the conventional liquid‐assisted process, whilst eliminating the risk of unwanted solvate formation as well as enabling control of resulting particle size. It represents a new approach for the development of functional materials through mechanochemistry, and possibly opens new routes toward the understanding of the mechanisms and pathways of mechanochemical cocrystal formation. Multicomponent crystals can be obtained by polymer‐assisted grinding (POLAG), an alternative to the liquid‐assisted grinding technique. POLAG is a new approach for the development of functional materials by mechanochemistry and may improve our understanding of the mechanisms and pathways of mechanochemical cocrystal formation.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501638