Gewald-type reaction of double activated 2,3-diarylcyclopropanes with elemental sulfur for synthesis of polysubstituted 2-aminothiophenes

A new synthetic procedure for the polysubstituted 2-aminothiophenes was developed via Gewald type ring-opening reaction of 1,1-dicyano-2,3-diarylcyclopropanes with elemental sulfur in N,N-dimethylformamide in the presence of morpholine as base.

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Bibliographic Details
Published in:Tetrahedron letters 2014-02, Vol.55 (8), p.1441-1443
Main Authors: Han, Ying, Tang, Wan-Quan, Yan, Chao-Guo
Format: Article
Language:English
Subjects:
Activated
Cyclopropane
Gewald reaction
Morpholine
Ring-opening reaction
Sulfur
Synthesis (chemistry)
Tetrahedrons
Thiophene
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Description
Summary:A new synthetic procedure for the polysubstituted 2-aminothiophenes was developed via Gewald type ring-opening reaction of 1,1-dicyano-2,3-diarylcyclopropanes with elemental sulfur in N,N-dimethylformamide in the presence of morpholine as base.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.01.043