Kinetic analysis of solid-state degradation of pure pravastatin versus pharmaceutical formulation

In this paper, the kinetic behavior of decomposition of a well-known bioactive substance used for treating dyslipidemia and the prevention of cardiovascular disease drug from statin class, namely pravastatin, was described. The kinetic study was performed on the main decomposition process which occu...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2015-09, Vol.121 (3), p.1103-1110
Main Authors: Ledeţi, Ionuţ, Vlase, Gabriela, Vlase, Titus, Fuliaş, Adriana
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Antilipemic agents
Biocompatibility
Calorimetry
Cardiovascular agents
Chemistry
Chemistry and Materials Science
Decomposition
Degradation
Formulations
Inorganic Chemistry
Measurement Science and Instrumentation
Pharmaceuticals
Physical Chemistry
Polymer Sciences
Pravastatin
Stability
Tablets
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Summary:In this paper, the kinetic behavior of decomposition of a well-known bioactive substance used for treating dyslipidemia and the prevention of cardiovascular disease drug from statin class, namely pravastatin, was described. The kinetic study was performed on the main decomposition process which occurs at nearly 200 °C, for both pure active substance and a generic commercial formulation that contain 40 mg pravastatin per tablet, using Kissinger, Friedman, Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa and NPK methods. The stability of pravastatin as pure active substance and as tablet was compared by means of kinetic data, and the results suggested that in the solid pharmaceutical formulation, PRV has an increased stability compared to pure active substance.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-015-4842-3