Elevated susceptibility of newborn as compared with young rats to 2-tert-butylphenol and 2,4-di-tert-butylphenol toxicity

ABSTRACT  In order to determine the susceptibility of newborn rats to 2‐tert‐butylphenol (2TBP) and 2,4‐di‐tert‐butylphenol (DTBP) toxicity, studies were conducted with oral administration from postnatal days (PND) 4 to 21 and the findings were compared with results for young rats exposed from 5 or...

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Published in:Congenital anomalies 2005-12, Vol.45 (4), p.146-153
Main Authors: Hirata-Koizumi, Mutsuko, Hamamura, Masao, Furukawa, Hiromi, Fukuda, Naemi, Ito, Yoshihiko, Wako, Yumi, Yamashita, Kotaro, Takahashi, Mika, Kamata, Eiichi, Ema, Makoto, Hasegawa, Ryuichi
Format: Article
Language:English
Subjects:
2,4‐di‐tert‐butylphenol
2-tert-butylphenol
4-di-tert-butylphenol
Age Factors
Animals
Animals, Newborn
Blood Chemical Analysis
Body Weight - drug effects
Dose-Response Relationship, Drug
Kidney - drug effects
Kidney - pathology
Liver - drug effects
Liver - pathology
No-Observed-Adverse-Effect Level
Organ Size - drug effects
Phenols - toxicity
Rats
Rats, Sprague-Dawley
susceptibility of newborn rats
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Summary:ABSTRACT  In order to determine the susceptibility of newborn rats to 2‐tert‐butylphenol (2TBP) and 2,4‐di‐tert‐butylphenol (DTBP) toxicity, studies were conducted with oral administration from postnatal days (PND) 4 to 21 and the findings were compared with results for young rats exposed from 5 or 6 weeks of age for 28 days. In the newborn rats, specific effects on physical and sexual development and reflex ontogeny were not observed. While there were no clear differences in toxicological profiles between newborn and young rats, the no‐observed‐adverse‐effect levels (NOAELs) differed markedly. For 2TBP, clinical signs such as ataxic gait, decrease in locomotor activity and effects on liver, such as increase in organ weight, were observed and the NOAELs were concluded to be 20 and 100 mg/kg/day in newborn and young rats, respectively. Based on hepatic and renal toxicity (histopathological changes and increase in organ weight with blood biochemical changes), the respective NOAELs for DTBP were concluded to be 5 and 20 mg/kg/day. Therefore, the susceptibility of newborn rats to 2TBP and DTBP was found to be 4–5 times higher than that of young rats.
ISSN:0914-3505
1741-4520
DOI:10.1111/j.1741-4520.2005.00084.x