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Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor
Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT...
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| Published in: | Immunopharmacology 1999-10, Vol.44 (1-2), p.199-204 |
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| Main Authors: | , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c390t-53e64745939a8616b7969da27cc65e1db820e431a6dd29ad14cb00e431829eda3 |
| container_end_page | 204 |
| container_issue | 1-2 |
| container_start_page | 199 |
| container_title | Immunopharmacology |
| container_volume | 44 |
| creator | Abe, Fumiaki Omata, Ken Yamada, Masaaki Tsunoda, Kazuo Sato, Tatsuyuki Shimizu, Tetsu Ito, Sadayoshi Abe, Keishi Nakazima, Megumi Morimoto, Taeko Takanashi, Naoki |
| description | Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT I and III was 0.037% and 21%, respectively. There were good correlation between the value measured by direct method, and that of extraction method (r=0.96, P |
| doi_str_mv | 10.1016/S0162-3109(99)00090-9 |
| format | article |
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Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT I and III was 0.037% and 21%, respectively. There were good correlation between the value measured by direct method, and that of extraction method (r=0.96, P<0.01) and plasma renin activity (r=0.80, P<0.01). By oral administration of ACE inhibitor (captopril 50 mg), AT II levels were suppressed to 10 pg/ml or less in most patients with essential hypertension, renal parenchymal hypertension and renovascular hypertension up to 2 h. However, AT II levels in patients treated with ACE inhibitors chronically were not different from the AT II levels in patients without ACE inhibitor. In primary aldosteronism AT II was extremely low levels. AT II markedly increased by the stimulation test using furosemide (1 mg/kg i.v.). These results suggest that this method may be useful to clarify the pathophysiology of hypertension and the escape of the inhibition by ACE inhibitor.</description><identifier>ISSN: 0162-3109</identifier><identifier>DOI: 10.1016/S0162-3109(99)00090-9</identifier><identifier>PMID: 10604545</identifier><identifier>CODEN: IMMUDP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Angiotensin converting enzyme (ACE) inhibitor ; Angiotensin II ; Angiotensin II - blood ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Biological and medical sciences ; captopril ; dipeptidyl carboxypeptidase I inhibitors ; Female ; General pharmacology ; Humans ; Hyperaldosteronism - blood ; Hyperaldosteronism - drug therapy ; Hypertension ; Hypertension - blood ; Hypertension - drug therapy ; Hypertension, Renal - blood ; Hypertension, Renal - drug therapy ; Medical sciences ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Complications, Cardiovascular - blood ; Pregnancy Complications, Cardiovascular - drug therapy ; Radioimmunoassay - methods ; Renin</subject><ispartof>Immunopharmacology, 1999-10, Vol.44 (1-2), p.199-204</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-53e64745939a8616b7969da27cc65e1db820e431a6dd29ad14cb00e431829eda3</citedby><cites>FETCH-LOGICAL-c390t-53e64745939a8616b7969da27cc65e1db820e431a6dd29ad14cb00e431829eda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,778,782,787,788,23917,23918,25127,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1209232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10604545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Fumiaki</creatorcontrib><creatorcontrib>Omata, Ken</creatorcontrib><creatorcontrib>Yamada, Masaaki</creatorcontrib><creatorcontrib>Tsunoda, Kazuo</creatorcontrib><creatorcontrib>Sato, Tatsuyuki</creatorcontrib><creatorcontrib>Shimizu, Tetsu</creatorcontrib><creatorcontrib>Ito, Sadayoshi</creatorcontrib><creatorcontrib>Abe, Keishi</creatorcontrib><creatorcontrib>Nakazima, Megumi</creatorcontrib><creatorcontrib>Morimoto, Taeko</creatorcontrib><creatorcontrib>Takanashi, Naoki</creatorcontrib><title>Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor</title><title>Immunopharmacology</title><addtitle>Immunopharmacology</addtitle><description>Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT I and III was 0.037% and 21%, respectively. There were good correlation between the value measured by direct method, and that of extraction method (r=0.96, P<0.01) and plasma renin activity (r=0.80, P<0.01). By oral administration of ACE inhibitor (captopril 50 mg), AT II levels were suppressed to 10 pg/ml or less in most patients with essential hypertension, renal parenchymal hypertension and renovascular hypertension up to 2 h. However, AT II levels in patients treated with ACE inhibitors chronically were not different from the AT II levels in patients without ACE inhibitor. In primary aldosteronism AT II was extremely low levels. AT II markedly increased by the stimulation test using furosemide (1 mg/kg i.v.). These results suggest that this method may be useful to clarify the pathophysiology of hypertension and the escape of the inhibition by ACE inhibitor.</description><subject>Analysis</subject><subject>Angiotensin converting enzyme (ACE) inhibitor</subject><subject>Angiotensin II</subject><subject>Angiotensin II - blood</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>captopril</subject><subject>dipeptidyl carboxypeptidase I inhibitors</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hyperaldosteronism - blood</subject><subject>Hyperaldosteronism - drug therapy</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension, Renal - blood</subject><subject>Hypertension, Renal - drug therapy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - blood</subject><subject>Pregnancy Complications, Cardiovascular - drug therapy</subject><subject>Radioimmunoassay - methods</subject><subject>Renin</subject><issn>0162-3109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u3CAQhzk0av60j9CKQxQlB7dgY7ycqmiVtitF6iHpGY1hnKWyYQt2pM0j5KnLrldNlUsvjBi--YE-CPnA2SfOuPx8l5eyqDhTl0pdMcYUK9QbcvK3fUxOU_qVD0Sj6rfkmDPJRC3qE_J8t0HjOmeodRHNSCNYF9wwTD5ASrCloaPgH1wY0Sfn6WpFL6_vc7miebeeBvB000MaIGOWjmuk2HW7pFeDJvhHjKPzDxT903bAnLO82aWsXevGEN-Row76hO8P9Yz8_Hpzv_xe3P74tlpe3xamUmws6gqlaEStKgULyWXbKKkslI0xskZu20XJUFQcpLWlAsuFadm-sygVWqjOyMWcu4nh94Rp1INLBvsePIYpad4IySsmMljPoIkhpYid3kQ3QNxqzvROvN6L1zvDWim9F69Vnvt4uGBqB7T_TM3WM3B-ACAZ6LsI3rj0wpVMlVWZsS8zhtnGo8Ook3HoDc5fpW1w_3nJH8yvoYY</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>Abe, Fumiaki</creator><creator>Omata, Ken</creator><creator>Yamada, Masaaki</creator><creator>Tsunoda, Kazuo</creator><creator>Sato, Tatsuyuki</creator><creator>Shimizu, Tetsu</creator><creator>Ito, Sadayoshi</creator><creator>Abe, Keishi</creator><creator>Nakazima, Megumi</creator><creator>Morimoto, Taeko</creator><creator>Takanashi, Naoki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19991015</creationdate><title>Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor</title><author>Abe, Fumiaki ; Omata, Ken ; Yamada, Masaaki ; Tsunoda, Kazuo ; Sato, Tatsuyuki ; Shimizu, Tetsu ; Ito, Sadayoshi ; Abe, Keishi ; Nakazima, Megumi ; Morimoto, Taeko ; Takanashi, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-53e64745939a8616b7969da27cc65e1db820e431a6dd29ad14cb00e431829eda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analysis</topic><topic>Angiotensin converting enzyme (ACE) inhibitor</topic><topic>Angiotensin II</topic><topic>Angiotensin II - blood</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>captopril</topic><topic>dipeptidyl carboxypeptidase I inhibitors</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hyperaldosteronism - blood</topic><topic>Hyperaldosteronism - drug therapy</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension, Renal - blood</topic><topic>Hypertension, Renal - drug therapy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - blood</topic><topic>Pregnancy Complications, Cardiovascular - drug therapy</topic><topic>Radioimmunoassay - methods</topic><topic>Renin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Fumiaki</creatorcontrib><creatorcontrib>Omata, Ken</creatorcontrib><creatorcontrib>Yamada, Masaaki</creatorcontrib><creatorcontrib>Tsunoda, Kazuo</creatorcontrib><creatorcontrib>Sato, Tatsuyuki</creatorcontrib><creatorcontrib>Shimizu, Tetsu</creatorcontrib><creatorcontrib>Ito, Sadayoshi</creatorcontrib><creatorcontrib>Abe, Keishi</creatorcontrib><creatorcontrib>Nakazima, Megumi</creatorcontrib><creatorcontrib>Morimoto, Taeko</creatorcontrib><creatorcontrib>Takanashi, Naoki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Fumiaki</au><au>Omata, Ken</au><au>Yamada, Masaaki</au><au>Tsunoda, Kazuo</au><au>Sato, Tatsuyuki</au><au>Shimizu, Tetsu</au><au>Ito, Sadayoshi</au><au>Abe, Keishi</au><au>Nakazima, Megumi</au><au>Morimoto, Taeko</au><au>Takanashi, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor</atitle><jtitle>Immunopharmacology</jtitle><addtitle>Immunopharmacology</addtitle><date>1999-10-15</date><risdate>1999</risdate><volume>44</volume><issue>1-2</issue><spage>199</spage><epage>204</epage><pages>199-204</pages><issn>0162-3109</issn><coden>IMMUDP</coden><abstract>Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma was developed to evaluate the dynamics of endogenous AT II in various types of hypertension. Detection limit of this method was less than 2.3 pg/ml, and normal value is less than 25 pg/ml. Cross reactivity of antibody with AT I and III was 0.037% and 21%, respectively. There were good correlation between the value measured by direct method, and that of extraction method (r=0.96, P<0.01) and plasma renin activity (r=0.80, P<0.01). By oral administration of ACE inhibitor (captopril 50 mg), AT II levels were suppressed to 10 pg/ml or less in most patients with essential hypertension, renal parenchymal hypertension and renovascular hypertension up to 2 h. However, AT II levels in patients treated with ACE inhibitors chronically were not different from the AT II levels in patients without ACE inhibitor. In primary aldosteronism AT II was extremely low levels. AT II markedly increased by the stimulation test using furosemide (1 mg/kg i.v.). These results suggest that this method may be useful to clarify the pathophysiology of hypertension and the escape of the inhibition by ACE inhibitor.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10604545</pmid><doi>10.1016/S0162-3109(99)00090-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Immunopharmacology, 1999-10, Vol.44 (1-2), p.199-204 |
| issn | 0162-3109 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Analysis Angiotensin converting enzyme (ACE) inhibitor Angiotensin II Angiotensin II - blood Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences captopril dipeptidyl carboxypeptidase I inhibitors Female General pharmacology Humans Hyperaldosteronism - blood Hyperaldosteronism - drug therapy Hypertension Hypertension - blood Hypertension - drug therapy Hypertension, Renal - blood Hypertension, Renal - drug therapy Medical sciences Pharmacology. Drug treatments Pregnancy Pregnancy Complications, Cardiovascular - blood Pregnancy Complications, Cardiovascular - drug therapy Radioimmunoassay - methods Renin |
| title | Specific direct radioimmunoassay of angiotensin II (AT II) in human plasma and the effect of angiotensin converting enzyme (ACE) inhibitor |
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