Male rats develop more severe experimental autoimmune encephalomyelitis than female rats: Sexual dimorphism and diergism at the spinal cord level

Highlights • More severe clinical and histological EAE in male than in female rats. • Spinal cord (SC) microglia/macrophages are more activated in male rats with EAE. • Male rat SC microglia/macrophages produce more proinflammatory cytokines. • Male rat SC favors CD4+ T-cell ingress and differentiat...

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Published in:Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.101-118
Main Authors: Nacka-Aleksić, Mirjana, Djikić, Jasmina, Pilipović, Ivan, Stojić-Vukanić, Zorica, Kosec, Duško, Bufan, Biljana, Arsenović-Ranin, Nevena, Dimitrijević, Mirjana, Leposavić, Gordana
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cuniculidae
EAE
Encephalomyelitis, Autoimmune, Experimental - immunology
Female
IL-17+ T cells
Immunization
Inflammation - immunology
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Macrophages - immunology
Male
Microglia
Microglia - immunology
Proinflammatory cytokines
Psychiatry
Rats
Severity of Illness Index
Sex Characteristics
Sexual dimorphism
Spinal Cord - immunology
Spinal Cord - pathology
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Summary:Highlights • More severe clinical and histological EAE in male than in female rats. • Spinal cord (SC) microglia/macrophages are more activated in male rats with EAE. • Male rat SC microglia/macrophages produce more proinflammatory cytokines. • Male rat SC favors CD4+ T-cell ingress and differentiation towards IL-17+ cells. • Male rat SC cytokines favor differentiation of highly pathogenic IL-17+IFN-γ+ cells.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.04.017