Fumonisin B−Glucose Reaction Products Are Less Toxic When Fed to Swine

The effects of fumonisin B−glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 μmol of total fumonisin B/kg (FB), 528 μmol of total FB−glucose adducts/kg (FB-G, 122 μmol of unreacted FB/kg), or 0 μmol of total FB/kg for 15 days to test the efficacy of the FB-G r...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2005-05, Vol.53 (10), p.4264-4271
Main Authors: Fernández-Surumay, Guillermo, Osweiler, Gary D, Yaeger, Michael J, Rottinghaus, George E, Hendrich, Suzanne, Buckley, Lucas K, Murphy, Patricia A
Format: Article
Language:English
Subjects:
Animal Feed
Animal productions
Animals
Apoptosis
Aspartate Aminotransferases - blood
Bilirubin - blood
Biological and medical sciences
detoxification (processing)
Diet
feed contamination
feed intake
fumonisin B-glucose adducts
fumonisins
Fumonisins - chemistry
Fumonisins - toxicity
Fundamental and applied biological sciences. Psychology
gamma-Glutamyltransferase - blood
glucose
Glucose - chemistry
hepatotoxicity
liver
Liver - pathology
liveweight gain
Necrosis
Swine
Terrestrial animal productions
toxicity
Vertebrates
Weight Gain
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Summary:The effects of fumonisin B−glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 μmol of total fumonisin B/kg (FB), 528 μmol of total FB−glucose adducts/kg (FB-G, 122 μmol of unreacted FB/kg), or 0 μmol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serum sphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopic examination of tissues from FB pigs showed generalized liver necrosis and apoptosis with marked cellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G group appeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-G products are less toxic to swine and may provide an detoxification approach in instances of widespread FB grain contamination (p < 0.05). Keywords: Fumonisin B; fumonisin B−glucose; detoxification; swine
ISSN:0021-8561
1520-5118
DOI:10.1021/jf0500076