Cloud cover-adjusted ultraviolet B irradiance and pancreatic cancer incidence in 172 countries

•We measured the association between UVB irradiance and pancreatic cancer incidence.•Higher UVB was associated with lower levels of pancreatic cancer incidence.•The relationship remained significant after controlling for several confounders.•The association may be explained through photosynthesis of...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2016-01, Vol.155 (Pt B), p.257-263
Main Authors: Garland, Cedric F., Cuomo, Raphael E., Gorham, Edward D., Zeng, Kenneth, Mohr, Sharif B.
Format: Article
Language:English
Subjects:
Dose-Response Relationship, Radiation
Epidemiology
Female
Humans
Incidence
International comparisons
Male
Pancreatic cancer
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Regression Analysis
Risk Factors
Ultraviolet rays
Ultraviolet Rays - adverse effects
UVB
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - epidemiology
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Summary:•We measured the association between UVB irradiance and pancreatic cancer incidence.•Higher UVB was associated with lower levels of pancreatic cancer incidence.•The relationship remained significant after controlling for several confounders.•The association may be explained through photosynthesis of vitamin D. Controversy exists regarding whether vitamin D deficiency could influence the etiology of pancreatic cancer. Several cohort studies have found that high serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with low risk of pancreatic cancer, while others have not. Low ultraviolet B irradiance is associated with high incidence of pancreatic cancer. Age-standardized pancreatic cancer incidence rates were obtained from GLOBOCAN in 2008. The association between cloud-adjusted UVB irradiance and age-standardized incidence rates of pancreatic cancer was analyzed using regression. Overall, the lower the cloud-adjusted UVB irradiance, the higher the incidence rate of pancreatic cancer. Residents of countries with low UVB irradiance had approximately 6 times the incidence rates as those in countries with high UVB irradiance (p
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2015.04.004