Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators

High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed w...

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Published in:Journal of inorganic biochemistry 2015-10, Vol.151, p.94-106
Main Authors: Lachowicz, Joanna Izabela, Nurchi, Valeria Marina, Crisponi, Guido, Jaraquemada-Pelaez, Maria de Guadalupe, Ostrowska, Małgorzata, Jezierska, Julia, Gumienna-Kontecka, Elżbieta, Peana, Massimiliano, Zoroddu, Maria Antonietta, Choquesillo-Lazarte, Duane, Niclós-Gutiérrez, Juan, González-Pérez, Josefa Maria
Format: Article
Language:English
Subjects:
Copper - chemistry
Crystallography, X-Ray
EPR
Iron Chelating Agents - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
NMR
Potentiometry
Pyrones - chemistry
X-Ray Diffraction
Zinc - chemistry
Zinc(II) copper(II) complexes
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Summary:High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed with essential metal ions, in order that these last ones do not perturb iron chelation. In the frame of our research on iron chelators we have designed and synthesized a series of tetradentate derivatives of kojic acid, and examined their binding properties toward Fe3+ and Al3+. In this paper, for a characterization of the behavior of the proposed iron chelating agents in biological fluids, their complex formation equilibria with copper(II) and zinc(II) ions have been fully characterized together with a speciation study, showing the degree at which the iron chelators interfere with the homeostatic equilibria of these two essential metal ions. The complete characterization of the complex formation equilibria of copper and zinc with a set of hydroxypyrone ligands is described, together with a speciation study, showing the degree at which the studied ligands interfere on the homeostatic equilibria of these two essential metal ions. [Display omitted] •Selectivity of iron hydroxypyrone chelators in the presence of copper and zinc ions•Comprehensive multi-technique study of copper and zinc complexes•The presence of nitrogen in the linker does not affect the stability of formed dinuclear complexes.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2015.08.011