Roles of Lipoproteins and Apolipoproteins in Particle Formation of Hepatitis C Virus

More than 160 million people worldwide are infected with hepatitis C virus (HCV), and cirrhosis and hepatocellular carcinoma induced by HCV infection are life-threatening diseases. HCV takes advantage of many aspects of lipid metabolism for an efficient propagation in hepatocytes. Due to the morphol...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2015-10, Vol.23 (10), p.618-629
Main Authors: Fukuhara, Takasuke, Ono, Chikako, Puig-Basagoiti, Francesc, Matsuura, Yoshiharu
Format: Article
Language:English
Subjects:
amphipathic α-helices
Apolipoproteins - metabolism
exchangeable apolipoproteins
Hepacivirus - chemistry
Hepacivirus - metabolism
Hepatitis C virus
hepato-tropism
Internal Medicine
lipoprotein
Lipoproteins - metabolism
Virion - metabolism
Virus Assembly
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Summary:More than 160 million people worldwide are infected with hepatitis C virus (HCV), and cirrhosis and hepatocellular carcinoma induced by HCV infection are life-threatening diseases. HCV takes advantage of many aspects of lipid metabolism for an efficient propagation in hepatocytes. Due to the morphological and physiological similarities of HCV particles to lipoproteins, lipid-associated HCV particles are named lipoviroparticles. Recent analyses have revealed that exchangeable apolipoproteins directly interact with the viral membrane to generate infectious HCV particles. In this review, we summarize the roles of lipid metabolism in the life cycle of HCV.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.07.007