Ovarian transposition in prepubescent and adolescent girls with cancer

• Published in: The lancet oncology 2013-12, Vol.14 (13), p.e601-e608
• Main Authors: Irtan, Sabine, Prof, Orbach, Daniel, MD, Helfre, Sylvie, MD, Sarnacki, Sabine, Prof
• Format: Article
• Language: English
• Subjects: Abdomen; Adolescent; Age; Birth weight; Cancer therapies; Cerebellar Neoplasms - pathology; Cerebellar Neoplasms - radiotherapy; Chemotherapy; Child; Children & youth; Ewings sarcoma; Female; Fertility; Fertility - radiation effects; Fertility Preservation - methods; Follow-Up Studies; Girls; Gynecologic Surgical Procedures - methods; Hematology, Oncology and Palliative Medicine; Hodgkin Disease - radiotherapy; Humans; Infertility; Infertility, Female - etiology; Infertility, Female - prevention & control; Medulloblastoma - pathology; Medulloblastoma - radiotherapy; Minimally Invasive Surgical Procedures; Neoplasms - radiotherapy; Oncology; Ovaries; Ovary - surgery; Pediatrics; Pelvic Neoplasms - radiotherapy; Pelvis; Pregnancy; Pregnancy Outcome; Puberty; Radiation therapy; Radiotherapy - adverse effects; Radiotherapy Dosage; Reproductive technologies; Rhabdomyosarcoma - radiotherapy; Surgery; Teenagers; Tumors; Urogenital Neoplasms - radiotherapy; Uterus; Vagina
• ISSN: 1470-2045; 1474-5488
• DOI: 10.1016/S1470-2045(13)70288-2

Summary Ovarian transposition was the first procedure proposed to preserve fertility in girls with cancer and is indicated for patients with tumours requiring pelvic radiation at doses of 42·0–58·4 Gy, much higher doses than those that can induce loss of ovarian function (4–20 Gy). Ovarian transposition is usually done after neoadjuvant chemotherapy and is completed by minimally invasive surgery or open surgery in case of concomitant resection of the abdominal tumour. According to the type of tumour, the ovaries are moved and placed in the paracolic gutters when the radiation field reaches the midline (for medulloblastoma or urogenital rhabdomyosarcoma), contralaterally to the tumour (for pelvic sarcomas), or in line with the iliac crests (for Hodgkin's lymphoma). However, in 10–14% of cases the procedure can fail to protect the ovaries. Although few long-term results in adults are available, normal hormonal function and pregnancies have been reported in a few long-term follow-up studies. In view of the continued development of fertility preservation techniques, ovarian transposition should be discussed at a multidisciplinary meeting at the time of cancer diagnosis.