Simple cardiovagal and adrenergic function tests in carotid artery stenosis patients as a potential tool for determining a transient autonomic dysfunction

• Published in: Clinical autonomic research 2015-12, Vol.25 (6), p.383-390
• Main Authors: Švigelj, Viktor, Šinkovec, Matjaž, Avbelj, Viktor, Trobec, Roman
• Format: Article
• Language: English
• Subjects: Adrenergic Agents - pharmacology; Aged; Autonomic Nervous System Diseases - diagnosis; Autonomic Nervous System Diseases - physiopathology; Baroreflex - drug effects; Baroreflex - physiology; Blood Pressure - drug effects; Blood Pressure - physiology; Cardiology; Carotid Stenosis - diagnosis; Carotid Stenosis - physiopathology; Cohort Studies; Diabetes; Endocrinology; Female; Gastroenterology; Heart Rate - drug effects; Heart Rate - physiology; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Ophthalmology; Research Article; Valsalva Maneuver - physiology
• ISSN: 0959-9851; 1619-1560
• DOI: 10.1007/s10286-015-0316-8

Purpose The arterial baroreflex depends on the integrity of the afferent limb, which can be quantified using the baroreceptor’s sensitivity (BRS) during the Valsalva maneuver (VM). The aim of this study was to evaluate, using autonomic nervous system tests, the autonomic function in patients after a carotid artery angioplasty (CAS). Methods We evaluated the changes in blood pressure (BP) during the VM (Valsalva ratio, BRS, sympathetic indexes) in 41 patients with symptomatic, unilateral, internal carotid artery stenosis. Results The Valsalva ratio between the baseline and the post-procedural day (1.3 ± 0.1 vs 1.44 ± 0.3; P  = 0.002) and the post-procedural day and a month later (1.44 ± 0.3 vs 1.3 ± 0.3; P  = 0.0002) revealed significant differences. This was confirmed with a cardiovagal BRS test. However, the adrenergic BRS did not reveal any differences. Sympathetic indexes [BP fall (SI1) and recovery during phase 2 (SI2)] showed differences for the periods before and a day after the treatment (36.9 ± 18.0 vs 27.2 ± 21.4 and 7.1 ± 13.1 vs 3.0 ± 8.2, respectively; P  = 0.004) and for SI1 a day and a month after the treatment (27.2 ± 21.4 vs 37.1 ± 21.8; P  = 0.036). The dynamic ranges between S1 and S3 (the difference in the BP between the baseline and the end of phase 2) were also different ( P  = 0.007 and P  = 0.044, respectively). Conclusion We found heterogeneous responses in the BP regulation obtained with the Valsalva maneuver in our patients; however, we could not confirm that CAS provoked any long-term autonomic dysfunction, except for 1 day after the procedure.