Severe cytomegalovirus-triggered autoimmune hemolytic anemia complicating vertically acquired HIV infection

The association of acute cytomegalovirus infection with severe autoimmune hemolysis has not yet been reported in patients with HIV infection. The case is described of a 9-month-old infant with congenital HIV-1 infection who presented with severe autoimmune hemolysis and a high cytomegalovirus viral...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2000-02, Vol.19 (1), p.57-60
Main Authors: Häusler, M, Schaade, L, Hutschenreuter, G, Hannig, U, Kusenbach, G
Format: Article
Language:English
Subjects:
AIDS-Related Opportunistic Infections - complications
Anemia, Hemolytic, Autoimmune - etiology
Cytomegalovirus
Cytomegalovirus Infections - complications
HIV Infections - complications
HIV Infections - transmission
HIV-1
Human immunodeficiency virus 1
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Male
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Summary:The association of acute cytomegalovirus infection with severe autoimmune hemolysis has not yet been reported in patients with HIV infection. The case is described of a 9-month-old infant with congenital HIV-1 infection who presented with severe autoimmune hemolysis and a high cytomegalovirus viral plasma load. Alternative causes of the hemolysis, such as drugs or other infections, were ruled out. After birth and after successful therapy of hemolysis, cytomegalovirus was not detected in the plasma, strongly suggesting a causal relationship between the hemolysis and cytomegalovirus infection. Severe autoimmune hemolysis should thus be considered as a cytomegalovirus-associated complication in HIV infection.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960050012