Microbial pathogens – an Indian platform for structure-based inhibitor design

Although efforts to initiate macromolecular crystallographic studies in India started in the mid-1970s at the Indian Institute of Science (IISc), Bengaluru and in the late 1970s at the Bhabha Atomic Research Centre, Mumbai, definitive preliminary results in the area at the two centres began to emerg...

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Bibliographic Details
Published in:Current science (Bangalore) 2015-03, Vol.108 (5), p.775-777
Main Author: Vijayan, M.
Format: Article
Language:English
Subjects:
Biology
Crystal structure
Drug design
Genomics
HIV
Molecular biology
Mycobacterium tuberculosis
OPINION
Pathogens
Research design
Tuberculosis
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Summary:Although efforts to initiate macromolecular crystallographic studies in India started in the mid-1970s at the Indian Institute of Science (IISc), Bengaluru and in the late 1970s at the Bhabha Atomic Research Centre, Mumbai, definitive preliminary results in the area at the two centres began to emerge only in the early 1980s. The efforts received a major impetus in 1983 when the Department of Science and Technology, New Delhi decided to handsomely support the Bengaluru centre under its Thrust Area Programme. The Bengaluru centre also came to be recognized as a national nucleus for the development of the area. By the 1990s, work in the area began to spread to different institutions in the country with the support of other granting agencies as well, such as the Department of Biotechnology and the Council of Scientific and Industrial Research, New Delhi. Macromolecular crystallography in India came of age by the turn of the century, although the expansion of the area in the country continued unabated even afterwards. Some of the programmes pursued then and continued to be pursued now such as those on lectins and plant viruses at Bengaluru and on mammalian secretions at the All India Institute of Medical Sciences, New Delhi, have a distinctly Indian flavour. However, it was felt that it was time to address problems which are still more directly relevant to India.
ISSN:0011-3891