Canonical and non-canonical Wnt signaling control the regeneration of amputated rodent vibrissae follicles

Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, particular to mammals, is capable of regeneration following partial amputation. The detailed internal mechanism of this phenomenon is still unclear. Development and regrowth of the hair f...

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Bibliographic Details
Published in:Journal of molecular histology 2016-02, Vol.47 (1), p.1-8
Main Authors: Yuan, Yan-Ping, Huang, Keng, Xu, Yan-Min, Chen, Xian-Cai, Li, Hai-Hong, Cai, Bo-Zhi, Liu, Yang, Zhang, Huan, Li, Yu, Lin, Chang-Min
Format: Article
Language:English
Subjects:
Animals
beta Catenin - genetics
beta Catenin - metabolism
Biomedical and Life Sciences
Biomedicine
Bone Morphogenetic Protein 1 - genetics
Bone Morphogenetic Protein 1 - metabolism
Bone Morphogenetic Protein Receptors - genetics
Bone Morphogenetic Protein Receptors - metabolism
Cell Biology
Dermis - metabolism
Dermis - transplantation
Developmental Biology
Dissection
Female
Gene Expression Regulation
Hair Follicle - metabolism
Hair Follicle - transplantation
Hedgehog Proteins - genetics
Hedgehog Proteins - metabolism
Life Sciences
Mice
Mice, Nude
Original Paper
Platelet-Derived Growth Factor - genetics
Platelet-Derived Growth Factor - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Notch - genetics
Receptors, Notch - metabolism
Regeneration - genetics
Vibrissae - metabolism
Vibrissae - transplantation
Wnt Proteins - genetics
Wnt Proteins - metabolism
Wnt Signaling Pathway - genetics
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Summary:Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, particular to mammals, is capable of regeneration following partial amputation. The detailed internal mechanism of this phenomenon is still unclear. Development and regrowth of the hair follicle depends on dermal-epidermal interaction within the hair follicle. Previous studies have shown that Wnt/β-catenin, Shh, Bmp, PDGF, TGF and Notch signals all take part in the development and growth of the hair follicle, and the Wnt/β-catenin signaling additionally plays an indispensable role in hair follicle morphogenesis and regrowth. In this study, we investigated the localization, as well as, protein levels of Wnt/β-catenin signaling molecules during amputated whisker follicle regeneration.
ISSN:1567-2379
1567-2387
DOI:10.1007/s10735-015-9648-x